Physiological parameters related to oocyte nuclear differentiation for the improvement of IVM/IVF outcomes in women and cattle

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dc.contributor.authorBuratini, Jose [UNESP]
dc.contributor.authorSoares, Ana Caroline Silva [UNESP]
dc.contributor.authorBarros, Rodrigo Garcia
dc.contributor.authorDellaqua, Thaisy Tino [UNESP]
dc.contributor.authorLodde, Valentina
dc.contributor.authorFranciosi, Federica
dc.contributor.authorDal Canto, Mariabeatrice
dc.contributor.authorRenzini, Mario Mignini
dc.contributor.authorLuciano, Alberto Maria
dc.contributor.institutionIstituti Clinici Zucchi
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Milan
dc.date.accessioned2022-05-01T10:18:58Z
dc.date.available2022-05-01T10:18:58Z
dc.date.issued2021-01-01
dc.description.abstractIn vitro maturation (IVM) has been applied in numerous different contexts and strategies in humans and animals, but in both cases it represents a challenge still far from being overcome. Despite the large dataset produced over the last two decades on the mechanisms that govern antral follicular development and oocyte metabolism and differentiation, IVM outcomes are still unsatisfactory. This review specifically focuses on data concerning the potential consequences of using supraphysiological levels of FSH during IVM, as well as on the regulation of oocyte chromatin dynamics and its utility as a potential marker of oocyte developmental competence. Taken together, the data revisited herein indicate that a significant improvement in IVM efficacy may be provided by the integration of pre-OPU patient-specific protocols preparing the oocyte population for IVM and more physiological culture systems mimicking more precisely the follicular environment that would be experienced by the recovered oocytes until completion of metaphase II.en
dc.description.affiliationBiogenesi Reproductive Medicine Centre - Eugin Group Istituti Clinici Zucchi
dc.description.affiliationDepartment of Structural and Functional Biology Sao Paulo State University
dc.description.affiliationReproductive and Developmental Biology Laboratory Department of Health Animal Science and Food Safety University of Milan
dc.description.affiliationUnespDepartment of Structural and Functional Biology Sao Paulo State University
dc.identifierhttp://dx.doi.org/10.1071/RD21278
dc.identifier.citationReproduction, Fertility and Development.
dc.identifier.doi10.1071/RD21278
dc.identifier.issn1448-5990
dc.identifier.issn1031-3613
dc.identifier.scopus2-s2.0-85118894569
dc.identifier.urihttp://hdl.handle.net/11449/233790
dc.language.isoeng
dc.relation.ispartofReproduction, Fertility and Development
dc.sourceScopus
dc.subjectbovine
dc.subjectchromatin configuration
dc.subjectcumulus cells
dc.subjectFSH
dc.subjectgerminal vesicle
dc.subjecthuman
dc.subjectin vitro maturation (IVM)
dc.subjectoocyte
dc.titlePhysiological parameters related to oocyte nuclear differentiation for the improvement of IVM/IVF outcomes in women and cattleen
dc.typeResenha

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