Apresentação clinica e fatores prognósticos presentes nos cães com linfoma cutâneo atendidos no hospital veterinário “governador laudo natel” entre 2008-2020: estudo retrospectivo de 80 casos.
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2021-12-09
Autores
Máximo, Larissa Godoi
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Universidade Estadual Paulista (Unesp)
Resumo
O linfoma cutâneo é uma enfermidade que compreende cerca de 3 a 8% de todos os linfomas em cães e 1% dos neoplasmas cutâneos. É uma doença que pode apresentar lesões cutâneas em patch, placas ou nodulares, que por vezes se apresentam de forma localizada ou disseminada pelo corpo. As lesões podem se apresentar ulceradas e com prurido, devido a um tropismo de linfócitos neoplásicos pela epiderme, derme e anexos cutâneos. O curso da doença costuma ser muito agressivo, de difícil controle e prognóstico desfavorável. Objetivou-se definir o perfil do paciente que é acometido por essa doença e, dessa forma, tentar encontrar fatores prognósticos que possam ajudar a definir a melhorar a conduta clínica para esses pacientes. Foram analisadas as fichas clinicas de 80 cães com diagnóstico de linfoma cutâneo e coletado dados como raça, sexo, idade, peso corporal, apresentação clínica das lesões, alterações sistêmicas e laboratoriais, tratamento de eleição, resposta terapêutica e tempo de sobrevida. Foi possível observar que essa enfermidade acomete mais cães de médio a grande porte, sem predileção sexual, com apresentação clínica mais nodular e disseminada, com baixa resposta aos tratamentos instituídos. Todos os fatores em que foi comparada a taxa de sobrevida obtiveram um p>0,05, o que significa que estatisticamente não interferiram no prognóstico desses pacientes.
Cutaneous lymphoma is a disease that comprises about 3 to 8% of all lymphomas in dogs and 1% of cutaneous neoplasms. It is a disease that can cause skin lesions in patches, plaques or nodules, which sometimes present in a localized or disseminated form throughout the body, and may contain ulcerated and itchy lesions, this is due to a tropism of neoplastic lymphocytes in the epidermis, dermis and cutaneous attachments. The course of the disease is usually very aggressive, difficult to control and has an unfavorable prognosis, because of this it aimed to define the profile of the patient who acquired this disease and, thus, try to find prognostic factors that can help to improve the clinical conduct of these animals. The medical records of 80 dogs diagnosed with cutaneous lymphoma were analyzed and data such as race, sex, age, body weight, clinical presentation of lesions, systemic and laboratory changes, treatment of choice, therapeutic response and survival time were collected. It was possible to observe that this disease affects more dogs of medium to large size, without sexual predilection, with a more nodular and widespread clinical presentation, with low response to the instituted treatments, all the factors in which the survival rate was compared obtained a p> 0.05, which means that they did not statistically interfere with the prognosis of these patients.
Cutaneous lymphoma is a disease that comprises about 3 to 8% of all lymphomas in dogs and 1% of cutaneous neoplasms. It is a disease that can cause skin lesions in patches, plaques or nodules, which sometimes present in a localized or disseminated form throughout the body, and may contain ulcerated and itchy lesions, this is due to a tropism of neoplastic lymphocytes in the epidermis, dermis and cutaneous attachments. The course of the disease is usually very aggressive, difficult to control and has an unfavorable prognosis, because of this it aimed to define the profile of the patient who acquired this disease and, thus, try to find prognostic factors that can help to improve the clinical conduct of these animals. The medical records of 80 dogs diagnosed with cutaneous lymphoma were analyzed and data such as race, sex, age, body weight, clinical presentation of lesions, systemic and laboratory changes, treatment of choice, therapeutic response and survival time were collected. It was possible to observe that this disease affects more dogs of medium to large size, without sexual predilection, with a more nodular and widespread clinical presentation, with low response to the instituted treatments, all the factors in which the survival rate was compared obtained a p> 0.05, which means that they did not statistically interfere with the prognosis of these patients.
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Câncer, Linfócitos, Sobrevida