Latex–collagen membrane: an alternative treatment for tibial bone defects

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dc.contributor.authorde Paiva, Marcela Britto
dc.contributor.authorPegorin Brasil, Giovana Sant’Ana [UNESP]
dc.contributor.authorChagas, Ana Laura Destro [UNESP]
dc.contributor.authorMacedo, Ana Paula
dc.contributor.authorRamos, Júnia
dc.contributor.authorIssa, João Paulo Mardegan
dc.contributor.authorGangrade, Ankit
dc.contributor.authorFloriano, Juliana Ferreira [UNESP]
dc.contributor.authorCaetano, Guilherme Ferreira
dc.contributor.authorLi, Bingbing
dc.contributor.authorFarhadi, Neda
dc.contributor.authorMandal, Kalpana
dc.contributor.authorDokmeci, Mehmet Remzi
dc.contributor.authorJucaud, Vadim
dc.contributor.authorHerculano, Rondinelli Donizetti [UNESP]
dc.contributor.authorShimano, Antonio Carlos
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionTerasaki Institute for Biomedical Innovation
dc.contributor.institutionImperial College London
dc.contributor.institutionUniversity Center of Hermínio Ometto Foundation (FHO)
dc.contributor.institutionCalifornia State University
dc.date.accessioned2023-07-29T13:59:58Z
dc.date.available2023-07-29T13:59:58Z
dc.date.issued2022-12-01
dc.description.abstractDue to the difficulty of consolidation, the risk of fractures, and the high cost of therapy, the orthopedic field views the restoration of bony defects or post-traumatic diseases as a significant issue. In recent years, efforts have been made toward guided bone regeneration as a viable solution. In this study, natural rubber latex (NRL) and latex–collagen (NRL-COL) membranes were developed and characterized, and their effects on bone regeneration in rat tibial lesions were assessed. According to the physicochemical findings, the hydrolyzed COL was effectively incorporated into the NRL membrane to produce a more robust membrane (348% increase in stress) and showed good biocompatibility for human dermal fibroblast cells and in hemolytic activity assay. According to bone analysis using computed microtomography, a substantial difference in bone volume (BV) was found among NRL, control (CONT), and NRL-COL. NRL-COL exhibited the greatest value for the bone volume/total volume ratio (BV/TV). The presence of NRL and COL was significant for the analysis of BV and BV/TV, respectively. All the experimental groups demonstrated a higher bone quality and fracture resistance, as shown by the mechanical properties of the bone. In the COL group, both neoformation of bone and total collagen levels were greater, indicating that treated defects had been closed and mature bone cells were present. Due to its angiogenic properties and the low cost of NRL membrane production, the NRL-COL membrane could be a good substitute for upcoming bone regeneration applications. Graphical Abstract: [Figure not available: see fulltext.]en
dc.description.affiliationBioengineering Laboratory Ribeirão Preto Medical School São Paulo University (USP), SP
dc.description.affiliationDepartment of Biotechnology and Bioprocess Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP
dc.description.affiliationDepartment of Dental Materials and Prosthesis School of Dentistry of Ribeirão Preto São Paulo University (USP), SP
dc.description.affiliationDepartment of Morphology Physiology and Basic Pathology School of Dentistry of Ribeirão Preto São Paulo University (USP), SP
dc.description.affiliationTerasaki Institute for Biomedical Innovation
dc.description.affiliationBotucatu Medical School São Paulo State University (UNESP), SP
dc.description.affiliationNational Heart and Lung Institute Imperial College London
dc.description.affiliationUniversity Center of Hermínio Ometto Foundation (FHO), SP
dc.description.affiliationDivision of Dermatology Department of Internal Medicine Ribeirão Preto Medical School São Paulo University (USP), SP
dc.description.affiliationAutonomy Research Center for STEAHM (ARCS) California State University
dc.description.affiliationUnespDepartment of Biotechnology and Bioprocess Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP
dc.description.affiliationUnespBotucatu Medical School São Paulo State University (UNESP), SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFoundation for the National Institutes of Health
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 1713685
dc.description.sponsorshipIdFoundation for the National Institutes of Health: 1R01GM126571-01
dc.description.sponsorshipIdFoundation for the National Institutes of Health: 1U01CA214411-01A1
dc.description.sponsorshipIdFAPESP: 2011/17411-8
dc.description.sponsorshipIdFAPESP: 2014/17526-8)
dc.description.sponsorshipIdFAPESP: 2017/19603-8
dc.description.sponsorshipIdFAPESP: 2017/20051-0
dc.description.sponsorshipIdCNPq: 317203/2021-5
dc.format.extent22019-22041
dc.identifierhttp://dx.doi.org/10.1007/s10853-022-08009-7
dc.identifier.citationJournal of Materials Science, v. 57, n. 48, p. 22019-22041, 2022.
dc.identifier.doi10.1007/s10853-022-08009-7
dc.identifier.issn1573-4803
dc.identifier.issn0022-2461
dc.identifier.scopus2-s2.0-85143614000
dc.identifier.urihttp://hdl.handle.net/11449/249012
dc.language.isoeng
dc.relation.ispartofJournal of Materials Science
dc.sourceScopus
dc.titleLatex–collagen membrane: an alternative treatment for tibial bone defectsen
dc.typeArtigo
unesp.author.orcid0000-0003-3817-8202[2]

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