Lymphomatoid Papulosis Type E Affecting the Palate: A Detailed Case Report and Review of Literature

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dc.contributor.authorSilveira, Heitor Albergoni [UNESP]
dc.contributor.authorRagusa Silva, Paula Verona [UNESP]
dc.contributor.authorPimentel, Bruna Gonçalves
dc.contributor.authorNogueira, Gustavo Milhomens
dc.contributor.authorChahud, Fernando
dc.contributor.authorBrunaldi, Mariângela Ottoboni
dc.contributor.authorLeón, Jorge Esquiche
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T13:51:45Z
dc.date.available2023-07-29T13:51:45Z
dc.date.issued2023-05-01
dc.description.abstractLymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30+lymphoproliferative disorders, characterized by chronic, recurrent, self-healing papules, small nodules, or ulcers. The clinicopathological features of LyP can mimic overt lymphomas. To date, about 27 intraoral LyP cases have been reported. Of them, only 2 cases were diagnosed as angioinvasive LyP (type E). Herein, we report a 24-year-old Brazilian man who presented a large ulcerated lesion on the hard palate with rapid evolution. Remarkably, there was no involvement of the skin or other mucous membranes. Microscopy revealed a lymphoid infiltrate constituted by medium-sized to large atypical cells, with angiocentric and angiodestructive features. The atypical cells showed immunopositivity for CD3, CD8, CD30, CD56, granzyme B, perforin, and focally for MUM1/IRF4. Ki-67 highlighted almost all atypical lymphoid cells, whereas EBER1/2 was negative. After 2 months of follow-up, the lesion healed completely. Although rare, LyP type E should be included in the differential diagnosis of oral ulcers.en
dc.description.affiliationOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)
dc.description.affiliationOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo, Ribeirão Preto
dc.description.affiliationDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São Paulo, Ribeirão Preto
dc.description.affiliationUnespOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)
dc.format.extent326-329
dc.identifierhttp://dx.doi.org/10.1097/DAD.0000000000002405
dc.identifier.citationAmerican Journal of Dermatopathology, v. 45, n. 5, p. 326-329, 2023.
dc.identifier.doi10.1097/DAD.0000000000002405
dc.identifier.issn1533-0311
dc.identifier.issn0193-1091
dc.identifier.scopus2-s2.0-85152973299
dc.identifier.urihttp://hdl.handle.net/11449/248718
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Dermatopathology
dc.sourceScopus
dc.subjectangioinvasive
dc.subjectdifferential diagnosis
dc.subjectlymphoma
dc.subjectlymphomatoid papulosis type E
dc.subjectlymphoproliferative disorder
dc.subjectoral cavity
dc.titleLymphomatoid Papulosis Type E Affecting the Palate: A Detailed Case Report and Review of Literatureen
dc.typeArtigo

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