Changes in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis

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dc.contributor.authorRibeiro, D. A.
dc.contributor.authorSilva, R. N.
dc.contributor.authorDarros, B. R.
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorMarques, MEA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:36:58Z
dc.date.available2014-05-20T13:36:58Z
dc.date.issued2004-01-01
dc.description.abstractWe investigated the changes of minor salivary glands during 4NQO-induced rat tongue carcinogenesis. Histopathological examinations of serous and mucous tongue salivary glands of 30 male Wistar rats were performed after 4, 12 and 20 weeks of 50 ppm 4NQO chronicle administration in drinking water. Ten rats were used as control. Morphometric results were expressed as volume density (Vv %) of each of the components. Histopathological and morphometric changes in the salivary glands were evident only at 20 weeks following 4NQO administration and they included a significant (P < 0.05) decreased in the mean Vv of the serous acini compared with the control group accompanied by abnormal acini (Vv=14 %). Neither mucous acini nor ducts demonstrated significant changes. In conclusion, minor salivary glands are involved in the progression of 4NQO-induced carcinoma.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, TOXICAN, Dept Patol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, TOXICAN, Dept Patol, Botucatu, SP, Brazil
dc.format.extent43-48
dc.identifier.citationIi Intercontinental Congress of Pathology. Bologna: Medimond Publishing Co, p. 43-48, 2004.
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/12742
dc.identifier.wosWOS:000225560400010
dc.language.isoeng
dc.publisherMedimond Publishing Co
dc.relation.ispartofIi Intercontinental Congress of Pathology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleChanges in minor salivary glands during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesisen
dc.typeTrabalho apresentado em evento
dcterms.rightsHolderMedimond Publishing Co
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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