Antifungal Activity of Maytenin and Pristimerin

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dc.contributor.authorGullo, Fernanda P. [UNESP]
dc.contributor.authorSardi, Janaina C. O. [UNESP]
dc.contributor.authorSantos, Vania A. F. F. M. [UNESP]
dc.contributor.authorSangalli-Leite, Fernanda [UNESP]
dc.contributor.authorPitangui, Nayla S. [UNESP]
dc.contributor.authorRossi, Suelen A. [UNESP]
dc.contributor.authorde Paula e Silva, Ana C. A. [UNESP]
dc.contributor.authorSoares, Luciana A. [UNESP]
dc.contributor.authorSilva, Julhiany F. [UNESP]
dc.contributor.authorOliveira, Haroldo C. [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.authorSilva, Dulce H. S. [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:20:49Z
dc.date.available2014-05-20T14:20:49Z
dc.date.issued2012-01-01
dc.description.abstractFungal infections in humans have increased alarmingly in recent years, particularly in immunocompromised individuals. Among the infections systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent and more severe in humans. The current high incidence of dermatophytosis is in humans, especially as the main etiologic agents Trichophyton rubrum and Trichophyton mentagrophytes. Molecules pristimerin and maytenin obtained from the plant Maytenus ilicifolia (Celastraceae) are known to show various pharmacological activities. This study aimed to evaluate the spectrum of antifungal activity of maytenin and pristimerin and their cytotoxicity in human keratinocytes (NOK cells of the oral mucosa). It was concluded that the best spectrum of antifungal activity has been shown to maytenin with MIC varying from 0.12 to 125 mg/L, although it is also active with pristimerin MIC ranging between 0.12 and 250 mg/L. Regarding the toxicity, both showed to have high IC50. The SI showed high pristimerin against some species of fungi, but SI maytenin was above 1.0 for all fungi tested, showing a selective action of fungi. However, when comparing the two substances, maytenin also showed better results. The two molecules can be a possible prototype with a broad spectrum of action for the development of new antifungal agents.en
dc.description.affiliationUNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPró-Reitoria de Pesquisa da UNESP (PROPe UNESP)
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1155/2012/340787
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 6, 2012.
dc.identifier.doi10.1155/2012/340787
dc.identifier.fileWOS000304986200001.pdf
dc.identifier.issn1741-427X
dc.identifier.lattes4702004904231248
dc.identifier.lattes1308042794786872
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.urihttp://hdl.handle.net/11449/26249
dc.identifier.wosWOS:000304986200001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleAntifungal Activity of Maytenin and Pristimerinen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes4702004904231248[12]
unesp.author.lattes3716273524139678[15]
unesp.author.lattes1308042794786872
unesp.author.orcid0000-0002-8059-0826[14]
unesp.author.orcid0000-0002-1516-7765[12]
unesp.author.orcid0000-0002-2115-8988[15]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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