Antimicrobial behavior of titanium coating with chlorhexidine-doped thin film exposed to a biofilm supplemented with nicotine

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dc.contributor.authorMatos, Adaias Oliveira
dc.contributor.authorRangel, Elidiane Cipriano [UNESP]
dc.contributor.authorBarão, Valentim Adelino Ricardo
dc.contributor.authorGregory, Richard Lee
dc.contributor.institutionUniversity of Detroit Mercy
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionIndiana University School of Dentistry
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:09:43Z
dc.date.available2023-07-29T16:09:43Z
dc.date.issued2023-01-01
dc.description.abstractBecause nicotine upregulates the growth of most oral bacteria, this in vitro study investigated the antimicrobial effect of chlorhexidine-doped thin film on commercially pure titanium against Fusobacterium nucleatum (F. nucleatum) biofilm supplemented with different concentrations of nicotine (0, 1, and 2 mg/mL). Biofilms were formed on a chlorhexidine-doped thin film on commercially-pure-titanium discs and compared to the control groups. Biofilm viability, total biofilm growth using a spectrophotometer, extracellular polysaccharide content, and pH variations were assessed as dependent variables. Data were submitted to ANOVA and Tukey honest significant difference tests (α=0.05). F. nucleatum biofilm growth was inhibited when exposed to chlorhexidine-doped thin film (p<0.05). Biofilm supplemented with nicotine did not impact the synthesis of EPS on the same type of treatment (p>0.05). The pH values were significantly increased with the increase of nicotine concentration (p<0.05). Chlorhexidine-doped thin film was effective in reducing F. nucleatum biofilm supplemented with nicotine.en
dc.description.affiliationDivision of Clinical Essentials and Simulation University of Detroit Mercy
dc.description.affiliationDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP), Sao Paulo
dc.description.affiliationDepartment of Biomedical Sciences and Comprehensive Care Indiana University School of Dentistry
dc.description.affiliationLaboratory of Technological Plasmas (LaPTec) Engineering College Sao Paulo State University (UNESP), Sao Paulo
dc.description.affiliationUnespLaboratory of Technological Plasmas (LaPTec) Engineering College Sao Paulo State University (UNESP), Sao Paulo
dc.format.extent228-235
dc.identifierhttp://dx.doi.org/10.4012/dmj.2022-168
dc.identifier.citationDental Materials Journal, v. 42, n. 2, p. 228-235, 2023.
dc.identifier.doi10.4012/dmj.2022-168
dc.identifier.issn1881-1361
dc.identifier.issn0287-4547
dc.identifier.scopus2-s2.0-85151313218
dc.identifier.urihttp://hdl.handle.net/11449/249808
dc.language.isoeng
dc.relation.ispartofDental Materials Journal
dc.sourceScopus
dc.subjectBiofilm
dc.subjectChlorhexidine
dc.subjectFusobacterium nucleatum
dc.subjectNicotine
dc.subjectTitanium
dc.titleAntimicrobial behavior of titanium coating with chlorhexidine-doped thin film exposed to a biofilm supplemented with nicotineen
dc.typeArtigo

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