Metabolic activity of the sticker's lymphosarcoma

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dc.contributor.authorRosa, Claudete Deguirmendjian [UNESP]
dc.contributor.authorRosa, Rubens [UNESP]
dc.contributor.authorRodrigues, Edson [UNESP]
dc.contributor.authorOcampos, Dario [UNESP]
dc.contributor.authorVuono, Laudinor de [UNESP]
dc.contributor.authorBacila, Metry [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.date.accessioned2014-05-27T03:11:43Z
dc.date.available2014-05-27T03:11:43Z
dc.date.issued1987-12-01
dc.description.abstract1. 1. Some parameters (glycolysis, respiration, levels of glycolytic enzymes) of the lymphoid cells from the Sticker's lymphosarcoma were established in order to better define the biochemical behavior of the venereal tumor of the dog. 2. 2. For comparative purposes lymphocytes from peripheral blood of normal tumor-bearing dogs were also studied. 3. 3. Lactic acid produced by the tumor cells during aerobic glycolysis is liberated in the reaction medium. 4. 4. Oxygen uptake is enhanced in the presence of succinate, but not with pyruvate, α-ketoglutarate, or malate as substrates. 5. 5. Higher levels of some of the enzymes from the glycolytic pathways as well as differences on the physicochemical and kinetic properties of the glycolytic regulatory enzymes are found in Sticker's tumor cells, when compared with the lymphocytes from peripheral blood of normal and tumor-bearing dogs. 6. 6. A fructose-bisphosphate positively modulated pyruvatekinase is found in the tumor cells. © 1987.en
dc.description.affiliationDepartamento de Ciências Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista Julio de Mesquita Filho São José dos Campos, São Paulo
dc.description.affiliationInstituto de Química Departamento de Bioquímica Universidade de São Paulo
dc.description.affiliationDepartamento de Zootecnia Setor de Ciências Agrárias Universidade Federal do Paraná, Caixa Postal 672, Curitiba, Pr
dc.description.affiliationUnespDepartamento de Ciências Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista Julio de Mesquita Filho São José dos Campos, São Paulo
dc.format.extent329-336
dc.identifierhttp://dx.doi.org/10.1016/0020-711X(87)90006-1
dc.identifier.citationInternational Journal of Biochemistry, v. 19, n. 4, p. 329-336, 1987.
dc.identifier.doi10.1016/0020-711X(87)90006-1
dc.identifier.issn0020-711X
dc.identifier.scopus2-s2.0-0023189420
dc.identifier.urihttp://hdl.handle.net/11449/130675
dc.identifier.wosWOS:A1987H527200006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Biochemistry
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectPyruvate kinase
dc.subjectAnimal model
dc.subjectCell respiration
dc.subjectDog
dc.subjectEtiology
dc.subjectGlycolysis
dc.subjectLymphatic system
dc.subjectLymphosarcoma
dc.subjectNonhuman
dc.subjectAnimals
dc.subjectDog Diseases
dc.subjectDogs
dc.subjectFemale
dc.subjectGlycolysis
dc.subjectLactates
dc.subjectLactic Acid
dc.subjectLymphocytes
dc.subjectLymphoma, Non-Hodgkin
dc.subjectMale
dc.subjectOxygen Consumption
dc.subjectPyruvate Kinase
dc.subjectSexually Transmitted Diseases
dc.subjectUrogenital Neoplasms
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titleMetabolic activity of the sticker's lymphosarcomaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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