Neonatally induced diabetes: liver glycogen storage in pregnant rats

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dc.contributor.authorIessi, Isabela Lovizutto [UNESP]
dc.contributor.authorBueno, Aline [UNESP]
dc.contributor.authorSinzato, Yuri Karen [UNESP]
dc.contributor.authorSpada, Ana Paula Machado [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorHeubel, MaricĂȘ Thereza Correa Domingues
dc.contributor.authorDamasceno, DĂ©bora Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Sagrado Coração Departamento de CiĂȘncias BiolĂłgicas LaboratĂłrio de Biologia
dc.date.accessioned2014-05-20T13:35:11Z
dc.date.available2014-05-20T13:35:11Z
dc.date.issued2012-04-01
dc.description.abstractThe aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.en
dc.description.affiliationUniversidade Estadual Paulista Departamento de Ginecologia e ObstetrĂ­cia LaboratĂłrio de Pesquisa Experimental de Ginecologia e ObstetrĂ­cia
dc.description.affiliationUniversidade Sagrado Coração Departamento de CiĂȘncias BiolĂłgicas LaboratĂłrio de Biologia
dc.description.affiliationUnespUniversidade Estadual Paulista Departamento de Ginecologia e ObstetrĂ­cia LaboratĂłrio de Pesquisa Experimental de Ginecologia e ObstetrĂ­cia
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent251-256
dc.identifierhttp://dx.doi.org/10.1590/S1516-89132012000200010
dc.identifier.citationBrazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012.
dc.identifier.doi10.1590/S1516-89132012000200010
dc.identifier.fileS1516-89132012000200010.pdf
dc.identifier.issn1516-8913
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.scieloS1516-89132012000200010
dc.identifier.urihttp://hdl.handle.net/11449/12088
dc.identifier.wosWOS:000303935600010
dc.language.isoeng
dc.publisherBrazilian Archives of Biology and Technology
dc.relation.ispartofBrazilian Archives of Biology and Technology
dc.relation.ispartofjcr0.676
dc.relation.ispartofsjr0,281
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectpregnancyen
dc.subjectraten
dc.subjecthyperglycemiaen
dc.subjectglycogen storage liveren
dc.subjectmild diabetesen
dc.subjecthyperglycemiaen
dc.titleNeonatally induced diabetes: liver glycogen storage in pregnant ratsen
dc.typeArtigo
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0002-9227-832X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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