Avaliação da resposta à quimioterapia primária em amostra de mulheres brasileiras com tumores de mama localmente avançados

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dc.contributor.authorPessoa, Eduardo Carvalho [UNESP]
dc.contributor.authorRodrigues, José Ricardo Paciência [UNESP]
dc.contributor.authorMichelin, Odair [UNESP]
dc.contributor.authorDe Luca, Heloisa Vespolli [UNESP]
dc.contributor.authorKamiya, Carla Priscila [UNESP]
dc.contributor.authorTraiman, Paulo [UNESP]
dc.contributor.authorUemura, Gilberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:22Z
dc.date.available2014-05-27T11:22:22Z
dc.date.issued2007-01-01
dc.description.abstractPURPOSE: to evaluate the loco-regional response to primary chemotherapy in patients with breast cancer at stages II and III. METHODS: a retrospective and analytical clinical study carried out in 97 patients with an average age of 52.2 years old, with breast cancer at stages II and III, attended from January 1993 to December 2004, and submitted to 3 to 4 cycles of primary chemotherapy with 5-fl uorouracil - 500 mg/m2, epirubicin - 50 mg/m2 and cyclophosphamide - 500 mg/m2 or doxorubicin - 50 mg/m2 e cyclophosphamide - 500 mg/m2, and then to loco-regional surgical conservative or radical surgical treatment. Chi-square and Fisher's exact tests were used to study the association among the variables (age, menopausal state, pre-chemotherapy tumoral volume, axillary condition, stage, therapeutic scheme and number of cycles), while Pearson's correlation coefficient was used for the quantitative variables (tumoral volume according to the anatomo-pathological study and the post-chemotherapy clinical tumoral volume. The significance level was 5%. RESULTS: there were 56.8% of cases at stage II and 43.2% at stage III. Approximately 50% of the patients received FEC50 and 50% AC. Objective clinical response with primary chemotherapy was obtained in 64.9% of the cases. Full clinical response occurred in 12.3% of patients, while full pathological response occurred in 10.3% of the cases. CONCLUSIONS: there was a statistically significant correlation between the number of cycles and the response to primary chemotherapy. Patients who received 4 cycles had better response than those who received 3 cycles. There was also a statistically significant concordance between the evaluation through clinical examination of the response to primary chemotherapy and the pathological findings. No statistically significant correlation was observed concerning age, menopausal status, tumoral volume, and pretreatment of axillary damage.en
dc.description.affiliationDepartamento de Ginecologia, Obstetrícia e Mastologia Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)
dc.description.affiliationDepartamento de Clínica Médica Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)
dc.description.affiliationCentro de Avaliação e Mastologia Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)
dc.description.affiliation, Distrito Rubião Jr., s/n, CEP 18618-970 - Botucatu/SP
dc.description.affiliationUnespDepartamento de Ginecologia, Obstetrícia e Mastologia Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)
dc.description.affiliationUnespDepartamento de Clínica Médica Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)
dc.description.affiliationUnespCentro de Avaliação e Mastologia Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)
dc.format.extent18-26
dc.identifierhttp://dx.doi.org/10.1590/S0100-72032007000100004
dc.identifier.citationRevista Brasileira de Ginecologia e Obstetricia, v. 29, n. 1, p. 18-26, 2007.
dc.identifier.doi10.1590/S0100-72032007000100004
dc.identifier.file2-s2.0-34247347329.pdf
dc.identifier.issn0100-7203
dc.identifier.lattes8334785337106990
dc.identifier.lattes9878648143577124
dc.identifier.scieloS0100-72032007000100004
dc.identifier.scopus2-s2.0-34247347329
dc.identifier.urihttp://hdl.handle.net/11449/69453
dc.language.isopor
dc.relation.ispartofRevista Brasileira de Ginecologia e Obstetrícia
dc.relation.ispartofsjr0,292
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBreast neoplasm/drug
dc.subjectNeoadjuvant therapy
dc.subjectRetrospective studies
dc.subjectTherapy
dc.titleAvaliação da resposta à quimioterapia primária em amostra de mulheres brasileiras com tumores de mama localmente avançadospt
dc.title.alternativeEvaluation of response to primary chemotherapy in Brazilian patients with locally advanced breast canceren
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rbgo/paboutj.htm#3
unesp.author.lattes8334785337106990
unesp.author.lattes9878648143577124
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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