ANTINOCICEPTIVE EFFECT OF AMITRAZ IN MICE AND RATS

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dc.contributor.authorQueirozneto, A.
dc.contributor.authorJuang, S. J.
dc.contributor.authorSouza, K. R.
dc.contributor.authorAkamatsu, A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:52Z
dc.date.available2014-05-20T15:21:52Z
dc.date.issued1994-06-01
dc.description.abstractAmitraz, a formamidine insecticide and acaricide used in veterinary practice, presents side effects related to its pharmacological activity on az-adrenergic receptors. The present study was undertaken to investigate the antinociceptive effect of amitraz in rats and mice. The tail-flick test was used to determine the duration of the antinociceptive effect of the intraperitoneal tip) administration of amitraz (1 and 2 mg/kg, 10 animals per group) in male Wistar rats weighing 180-220 g. The writhing test (using 10 ml/kg of a 0.6% acetic acid solution as a painful stimulus). was performed in 140 male Swiss mice weighing 20-30 g, divided into 14 groups that received ip injections of saline, amitraz (0.5, 1.0, 1.5, 2.0 and 4.0 mg/kg), xylazine or detomidine (1.0, 1.5, 2.0 and 4.0 mg/ kg), in order to compare the effect of amitraz to that caused by xylazine and detomidine, and to investigate the participation of alpha(2)-adrenergic receptors which were blocked by idazoxan (1 mg/kg). Amitraz induced a significant antinociceptive effect in both rats and mice. This effect is blocked in mice by idazoxan.en
dc.description.affiliationUNESP,FAC CIENCIAS AGR & VET JABOTICABAL,DEPT MORFOL & FISIOL ANIM,BR-14870000 JABOTICABAL,SP,BRAZIL
dc.description.affiliationUnespUNESP,FAC CIENCIAS AGR & VET JABOTICABAL,DEPT MORFOL & FISIOL ANIM,BR-14870000 JABOTICABAL,SP,BRAZIL
dc.format.extent1407-1411
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 27, n. 6, p. 1407-1411, 1994.
dc.identifier.issn0100-879X
dc.identifier.urihttp://hdl.handle.net/11449/32945
dc.identifier.wosWOS:A1994NT47600016
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAmitrazpt
dc.subjectANTINOCICEPTIVE EFFECTpt
dc.subjectALPHA(2)-ADRENERGIC AGONISTSpt
dc.subjectIDAZOXANpt
dc.subjectXYLAZINEpt
dc.subjectDETOMIDINEpt
dc.subjectTAIL FLICK TESTpt
dc.subjectWRITHING TESTpt
dc.titleANTINOCICEPTIVE EFFECT OF AMITRAZ IN MICE AND RATSen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm
dcterms.rightsHolderAssociação Bras Divulg Cientifica
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Morfologia e Fisiologia Animal - FCAV