Morphofunctional changes in Leydig cells throughout the continuous spermatogenesis of the freshwater teleost fish, Serrasalmus spilopleura (Characiformes, Characidae): an ultrastructural and enzyme study

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dc.contributor.authorNobrega, R. H.
dc.contributor.authorQuagio-Grassiotto, I.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:09Z
dc.date.available2014-05-20T15:21:09Z
dc.date.issued2007-08-01
dc.description.abstractThe freshwater fish Serrasalmus spilopleura (piranha) has a continuous type of reproduction; gametes are constantly produced and released during the reproductive cycle. The testes do not undergo seasonal morphological changes but exhibit two constant regions throughout the year: the medullar region (involved with spermatogenesis) and the cortical region (involved with spermiation and sperm storage). We have evaluated the ultrastructure of the Leydig cells and the activity of 3 beta-HSD (an essential enzyme related to steroid hormone biosynthesis) and acid phosphatase (AcPase; lysosomal marker enzyme) in these two regions. The activity of 3 beta-HSD is stronger in the medullar region, and the Leydig cells in this region have a variety of cytological features that reflect differences in hormone synthesis and/or that could be linked to steroidogenic cells under various degrees of hormonal activity. In the cortical region, 3 beta-HSD activity is weak and the Leydig cells exhibit signs of degeneration, as confirmed by their ultrastructure and intense AcPase activity. These degenerative signs are indicative of cytoplasmic remodelling to degrade steroidogenic enzymes, such as 3 beta-HSD, that could lead to senescence or even to autophagic cell degeneration. S. spilopleura thus constitutes an interesting model for increasing our understanding of steroidogenesis control in freshwater teleost fish.en
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biol Celular, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Morfol, CP 510, BR-18618000 Botucatu, SP, Brazil.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 03/11078-9
dc.description.sponsorshipIdFAPESP: 04/01262-0
dc.format.extent339-349
dc.identifierhttp://dx.doi.org/10.1007/s00441-006-0377-z
dc.identifier.citationCell and Tissue Research. New York: Springer, v. 329, n. 2, p. 339-349, 2007.
dc.identifier.doi10.1007/s00441-006-0377-z
dc.identifier.issn0302-766X
dc.identifier.urihttp://hdl.handle.net/11449/32320
dc.identifier.wosWOS:000247932400014
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCell and Tissue Research
dc.relation.ispartofjcr3.043
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLeydig cellspt
dc.subjectUltrastructurept
dc.subject3 beta-HSDpt
dc.subjectAcid phosphatasept
dc.subjectSerrasalmus spilopleurapt
dc.subjectpirambeba/piranha (Teleostei)pt
dc.titleMorphofunctional changes in Leydig cells throughout the continuous spermatogenesis of the freshwater teleost fish, Serrasalmus spilopleura (Characiformes, Characidae): an ultrastructural and enzyme studyen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.orcid0000-0001-9796-5076[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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