Chronotropic response of beta-adrenergic-, muscarinic-, and calcitonin gene-related peptide-receptor agonists in right atria from neonatal capsaicin-treated rats

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dc.contributor.authorGasparetti, A. L.
dc.contributor.authorHyslop, S.
dc.contributor.authorCosta, SKP
dc.contributor.authorPriviero, FBM
dc.contributor.authorDe Nucci, G.
dc.contributor.authorAntunes, E.
dc.contributor.authorZanesco, A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T15:20:38Z
dc.date.available2014-05-20T15:20:38Z
dc.date.issued2002-06-14
dc.description.abstractWe evaluated the potency of isoproterenol, carbachol, pilocarpine and calcitonin gene-related peptide (CGRP) in the rat right atria at 30, 60 and 90 days after neonatal capsaicin treatment. Neonatal rats were pretreated on the second day of life with capsaicin (50 mg/kg). The capsaicin pretreatment caused a five-fold rightward shift at the pEC(50) level on the concentration-response curves to isoproterenol in 30-day-old rats. Propranolol (10 mg/kg, given 15 min prior to capsaicin treatment) prevented this subsensitivity. No changes in the potency of isoproterenol were observed at 60 and 90 days after capsaicin pretreatment. The potency and maximal responses of CGRP in the right atria in 30-day-old rats were significantly higher than in 60- and 90-day-old rats; however, no differences were found between control and capsaicin groups. The potency and maximal responses to carbachol and pilocarpine were not changed in all groups. The neonatal capsaicin treatment reduced by about 74% the CGRP content in the heart in all groups. In summary, capsaicin treatment in newborn rats produces a desensitization of chronotropic response mediated by beta-adrenoceptors in isolated right atria from 30-day-old rats possibly due to a massive release of catecholamines. (C) 2002 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUNESP, Biosci Inst, Dept Educ Phys, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUNICAMP, Fac Med Sci, Dept Pharmacol, BR-13081970 Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Educ Phys, BR-13506900 Rio Claro, SP, Brazil
dc.format.extent147-150
dc.identifierhttp://dx.doi.org/10.1016/S0304-3940(02)00134-9
dc.identifier.citationNeuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 325, n. 3, p. 147-150, 2002.
dc.identifier.doi10.1016/S0304-3940(02)00134-9
dc.identifier.issn0304-3940
dc.identifier.lattes4472007237545596
dc.identifier.urihttp://hdl.handle.net/11449/31889
dc.identifier.wosWOS:000176622200001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.relation.ispartofjcr2.159
dc.relation.ispartofsjr0,946
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcapsaicinpt
dc.subjectsensory fiberspt
dc.subjectbeta-adrenoceptorspt
dc.subjectmuscarinic receptorspt
dc.subjectheartpt
dc.subjectchronotropic responsept
dc.subjectright atriapt
dc.titleChronotropic response of beta-adrenergic-, muscarinic-, and calcitonin gene-related peptide-receptor agonists in right atria from neonatal capsaicin-treated ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4472007237545596
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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