Analysis of systemic inflammatory response in the carcinogenic process of uterine cervical neoplasia

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dc.contributor.authorLopes e Lages, Elisa [UNESP]
dc.contributor.authorBelo, Andrezza Vilaca
dc.contributor.authorAndrade, Silvia Passos
dc.contributor.authorRocha, Monaliza Angela
dc.contributor.authorFreitas, Gustavo Ferreira de [UNESP]
dc.contributor.authorLamaita, Rivia Mara [UNESP]
dc.contributor.authorTraiman, Paulo [UNESP]
dc.contributor.authorSilva-Filho, Agnaldo Lopes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2014-05-20T13:35:27Z
dc.date.available2014-05-20T13:35:27Z
dc.date.issued2011-10-01
dc.description.abstractThe inflammatory response is an active process in cervical cancer and may act in the progression and/or regression of the lesion. At the site of inflammation, macrophages and neutrophils are present as well as cytokines such as TNF-alpha and IFN-gamma. This study aims to evaluate the inflammatory response levels in women with cervical intraepithelial lesions (CIN) and with squamous cell carcinoma (SCC) of the cervix. Serum samples obtained from women without evidence of disease (n = 30), with CIN (n = 30) and with SCC of the cervix (n = 30) were analyzed for the activities of N-acetylglucosaminidase (NAG) and myeloperoxidase (MPO) by enzymatic assay and the serum levels of TNF-alpha and IFN-gamma by ELISA assay. The activities of NAG and MPO and the level of TNF-alpha were higher in women with CIN compared to the women with SCC. The levels of IFN-gamma were lower in the group of women with CIN compared to the group with SCC. There was not a significant association between the degree of the CIN and the staging of the SCC of the cervix and the degree of inflammation as assessed by the levels of inflammatory markers. The inflammatory response was inversely correlated with the progression of the carcinogenic process. In the three groups, the control group, women with CIN and women with invasive SCC, there was no association between the degree of preinvasive lesions and staging of the SCC of the cervix. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Botucatu, SP, Brazil
dc.description.affiliationFed Univ Minas Gerais UFMG, Fac Med, Dept Gynecol & Obstet, Sch Med, BR-30130100 Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de Minas Gerais (UFMG), Dept Physiol & Pharmacol, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Botucatu, SP, Brazil
dc.description.sponsorshipPrPq-UFMG
dc.format.extent496-499
dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2011.06.010
dc.identifier.citationBiomedicine & Pharmacotherapy. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 65, n. 7, p. 496-499, 2011.
dc.identifier.doi10.1016/j.biopha.2011.06.010
dc.identifier.issn0753-3322
dc.identifier.lattes8334785337106990
dc.identifier.urihttp://hdl.handle.net/11449/12198
dc.identifier.wosWOS:000296965100007
dc.language.isoeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.relation.ispartofjcr3.457
dc.relation.ispartofsjr0,951
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCervical canceren
dc.subjectN-acetylglucosaminidase (NAG)en
dc.subjectMyeloperoxidase (MPO)en
dc.titleAnalysis of systemic inflammatory response in the carcinogenic process of uterine cervical neoplasiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier France-editions Scientifiques Medicales Elsevier
unesp.author.lattes8334785337106990
unesp.author.orcid0000-0002-8486-7861[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB