Effect of L-arginine, dimercaptosuccinic acid (DMSA) and the association of L-arginine and DMSA on tissue lead mobilization and blood pressure level in plumbism

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dc.contributor.authorMalvezzi, C.K. [UNESP]
dc.contributor.authorMoreira, E.G. [UNESP]
dc.contributor.authorVassilieff, I. [UNESP]
dc.contributor.authorVassilieff, V.S. [UNESP]
dc.contributor.authorCordellini, S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:11:32Z
dc.date.available2014-05-20T15:11:32Z
dc.date.issued2001-10-01
dc.description.abstractLead (Pb)-induced hypertension is characterized by an increase in reactive oxygen species (ROS) and a decrease in nitric oxide (NO). In the present study we evaluated the effect of L-arginine (NO precursor), dimercaptosuccinic acid (DMSA, a chelating agent and ROS scavenger), and the association of L-arginine/DMSA on tissue Pb mobilization and blood pressure levels in plumbism. Tissue Pb levels and blood pressure evolution were evaluated in rats exposed to: 1) Pb (750 ppm, in drinking water, for 70 days), 2) Pb plus water for 30 more days, 3) Pb plus DMSA (50 mg kg-1 day-1, po), L-arginine (0.6%, in drinking water), and the combination of L-arginine/DMSA for 30 more days, and 4) their respective matching controls. Pb exposure increased Pb levels in the blood, liver, femur, kidney and aorta. Pb levels in tissues decreased after cessation of Pb administration, except in the aorta. These levels did not reach those observed in nonintoxicated rats. All treatments mobilized Pb from the kidney, femur and liver. Pb mobilization from the aorta was only effective with the L-arginine/DMSA treatment. Blood Pb concentrations in Pb-treated groups were not different from those of the Pb/water group. Pb increased blood pressure starting from the 5th week. L-arginine and DMSA treatments (4th week) and the combination of L-arginine/DMSA (3rd and 4th weeks) decreased blood pressure levels of intoxicated rats. These levels did not reach those of nonintoxicated rats. Treatment with L-arginine/DMSA was more effective than the isolated treatments in mobilizing Pb from tissues and in reducing the blood pressure of intoxicated rats.en
dc.description.affiliationUniversidade Estadual Paulista Instituto de Biociências Departamento de Farmacologia
dc.description.affiliationUniversidade Estadual Paulista Instituto de Biociências Centro de Assistência Toxicológica (CEATOX)
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Biociências Departamento de Farmacologia
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Biociências Centro de Assistência Toxicológica (CEATOX)
dc.format.extent1341-1346
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2001001000016
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 10, p. 1341-1346, 2001.
dc.identifier.doi10.1590/S0100-879X2001001000016
dc.identifier.fileS0100-879X2001001000016.pdf
dc.identifier.issn0100-879X
dc.identifier.lattes5616488317690037
dc.identifier.scieloS0100-879X2001001000016
dc.identifier.scopus2-s2.0-0034752119
dc.identifier.urihttp://hdl.handle.net/11449/28065
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectL-arginineen
dc.subjectDMSAen
dc.subjecttissue lead mobilizationen
dc.subjectplumbismen
dc.subjectblood pressureen
dc.subjectraten
dc.titleEffect of L-arginine, dimercaptosuccinic acid (DMSA) and the association of L-arginine and DMSA on tissue lead mobilization and blood pressure level in plumbismen
dc.typeArtigo
unesp.author.lattes5616488317690037

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Botucatu - CEATOX - Centro de Assistência Toxicológica