Effect of exercise training on the cardiovascular and biochemical parameters in women with eNOS gene polymorphism

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dc.contributor.authorRezende, Tiago M. [UNESP]
dc.contributor.authorSponton, Carlos H.G. [UNESP]
dc.contributor.authorMalagrino, Pamella A. [UNESP]
dc.contributor.authorBezerra, Marcos A.C.
dc.contributor.authorPenteado, Carla F.F.
dc.contributor.authorZanesco, Angelina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:26:15Z
dc.date.available2014-05-27T11:26:15Z
dc.date.issued2011-12-01
dc.description.abstractContext: Presence of endothelial nitric oxide synthase (eNOS) gene polymorphism has been associated with cardiovascular disease (CVD) whereas exercise training (EX) promotes beneficial effects on CVD which is related to increased nitric oxide levels (NO). Objective: To evaluate if women with eNOS gene polymorphism at position-G894T would be less responsive to EX than those who did not carry T allele. Methods: Women were trained 3 days/week, 40 minutes session during 6 months. Cardio-biochemical parameters and genetic analysis were performed in a double-blind fashion. Results: Plasma NOx - levels were similar in both groups at baseline (GG genotype: 18.44±3.28 μM) and (GT + TT genotype: 17.19±2.43 μM) and after EX (GG: 29.20±4.33 and GT+TT: 27.38±3.12 μM). A decrease in blood pressure was also observed in both groups. Discussion and conclusion: The presence of eNOS polymorphism does not affect the beneficial effects of EX in women. © 2011 Informa UK, Ltd.en
dc.description.affiliationLaboratory of Cardiovascular Research and Physical Activity Institute of Bioscience University of São Paulo State (UNESP), Rio Claro (SP)
dc.description.affiliationHematology and Hemotherapy Center School of Medicine UNICAMP, Campinas (SP)
dc.description.affiliationUnespLaboratory of Cardiovascular Research and Physical Activity Institute of Bioscience University of São Paulo State (UNESP), Rio Claro (SP)
dc.format.extent265-269
dc.identifierhttp://dx.doi.org/10.3109/13813455.2011.596548
dc.identifier.citationArchives of Physiology and Biochemistry, v. 117, n. 5, p. 265-269, 2011.
dc.identifier.doi10.3109/13813455.2011.596548
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.lattes4472007237545596
dc.identifier.scopus2-s2.0-82455171766
dc.identifier.urihttp://hdl.handle.net/11449/72899
dc.language.isoeng
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.ispartofjcr1.806
dc.relation.ispartofsjr0,626
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectNitric oxide
dc.subjectPhysical training
dc.subjectWomen
dc.subjectendothelial nitric oxide synthase
dc.subjectnitric oxide
dc.subjectNOS3 protein, human
dc.subjectallele
dc.subjectbiosynthesis
dc.subjectblood
dc.subjectblood pressure
dc.subjectBrazil
dc.subjectcardiovascular disease
dc.subjectcase control study
dc.subjectdouble blind procedure
dc.subjectenzymology
dc.subjectexercise
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetics
dc.subjectgenotype
dc.subjecthuman
dc.subjectmiddle aged
dc.subjectsingle nucleotide polymorphism
dc.subjectAlleles
dc.subjectBlood Pressure
dc.subjectCardiovascular Diseases
dc.subjectCase-Control Studies
dc.subjectDouble-Blind Method
dc.subjectExercise
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectNitric Oxide
dc.subjectNitric Oxide Synthase Type III
dc.subjectPolymorphism, Single Nucleotide
dc.titleEffect of exercise training on the cardiovascular and biochemical parameters in women with eNOS gene polymorphismen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
unesp.author.lattes4472007237545596
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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