The acute phase response in bats (Carollia perspicillata) varies with time and dose of the immune challenge

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dc.contributor.authorViola, Matheus F. [UNESP]
dc.contributor.authorHerrera, L. Gerardo
dc.contributor.authorda Cruz-Neto, Ariovaldo P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAutónoma de México
dc.date.accessioned2023-07-29T13:33:41Z
dc.date.available2023-07-29T13:33:41Z
dc.date.issued2022-12-01
dc.description.abstractThe acute phase response (APR) is a core component of the innate immune response and represents the first line of immune defense used in response to infections. Although several studies with vertebrates reported fever, a decrease in food intake and body mass, and an increase in neutrophil/lymphocyte ratio and total white blood cell count after lipopolysaccharide (LPS) inoculation, there was great variability in the magnitude of these responses. Some of these differences might reflect, to some extent, differences in the time of endotoxin inoculation (during active or rest periods) and dose. Therefore, our study tested the interplay between LPS dose and time of injection on selected physiological (fever and increase in total white blood cell count and neutrophil/lymphocyte ratio) and behavioral (food intake) components of the APR using a Neotropical fruit-eating bat (Carollia perspicillata) as a model organism. We predicted that LPS would trigger a dose- and time-dependent response in APR components. APR components were assessed in rest and active periods after injection of three doses of LPS (5, 10 and 15 mg kg-1 LPS). The results indicate a more robust decrease in food intake at higher doses during the active period, while increased neutrophil/lymphocyte ratio was more robust during the active period regardless of dose. Furthermore, the skin temperature increase lasted longer at higher doses regardless of the timing of injections. Our study offers important insights into the dependence of time as well as the LPS dosage effect in the APR of bats, and how they deal with the magnitude of infections at different times of day.en
dc.description.affiliationLaboratório de Fisiologia Animal (LaFA) Departamento de Biodiversidade Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Rio Claro
dc.description.affiliationEstación de Biologıá Chamela Instituto de Biologıá Universidad Nacional Autónoma de México, Jalisco
dc.description.affiliationUnespLaboratório de Fisiologia Animal (LaFA) Departamento de Biodiversidade Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Rio Claro
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidad Nacional Autónoma de México
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2014/16320-7
dc.description.sponsorshipIdFAPESP: 2017–17607–6
dc.description.sponsorshipIdUniversidad Nacional Autónoma de México: 814-2018
dc.description.sponsorshipIdCAPES: 88882.434214/2019-01
dc.identifierhttp://dx.doi.org/10.1242/jeb.244583
dc.identifier.citationJournal of Experimental Biology, v. 225, n. 24, 2022.
dc.identifier.doi10.1242/jeb.244583
dc.identifier.issn1477-9145
dc.identifier.issn0022-0949
dc.identifier.scopus2-s2.0-85144592161
dc.identifier.urihttp://hdl.handle.net/11449/248073
dc.language.isoeng
dc.relation.ispartofJournal of Experimental Biology
dc.sourceScopus
dc.subjectActivity period
dc.subjectChiroptera
dc.subjectInnate immune response
dc.subjectLipopolysaccharide
dc.subjectResting period
dc.titleThe acute phase response in bats (Carollia perspicillata) varies with time and dose of the immune challengeen
dc.typeArtigo
unesp.author.orcid0000-0003-1889-7584[1]

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Artigos - Zoologia - IBRC