Effect of Qualea multiflora on Macrophages and Tumour Cells
| dc.contributor.author | Carli, Camila B. de A. [UNESP] | |
| dc.contributor.author | Quilles, Marcela B. [UNESP] | |
| dc.contributor.author | Vilegas, Wagner [UNESP] | |
| dc.contributor.author | Carlos, Iracilda Zeppone [UNESP] | |
| dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
| dc.date.accessioned | 2014-12-03T13:08:36Z | |
| dc.date.available | 2014-12-03T13:08:36Z | |
| dc.date.issued | 2013-01-01 | |
| dc.description.abstract | Species of the genus Qualea are used by the Brazilian people as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions beta F and TF (rich in beta-sitosterol and terpenoids, respectively) obtained from Qualea multiflora on nitric oxide production, cytokines (IL-1, IL-10, IL-12, and TNF-alpha) and the transcription factor NF-kappa B by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of beta F and TF against mammary and pulmonary tumoural cell lineages, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-alpha; about 32% of NF-kappa B; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to beta F and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted. | en |
| dc.description.affiliation | UNESP Sao Paulo State Univ, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | |
| dc.description.affiliation | UNESP Sao Paulo State Univ, Inst Quim Araraquara, BR-14801970 Araraquara, SP, Brazil | |
| dc.description.affiliationUnesp | UNESP Sao Paulo State Univ, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | |
| dc.description.affiliationUnesp | UNESP Sao Paulo State Univ, Inst Quim Araraquara, BR-14801970 Araraquara, SP, Brazil | |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.format.extent | 1516-1521 | |
| dc.identifier | http://www.latamjpharm.org/resumenes/32/10/LAJOP_32_10_1_12.pdf | |
| dc.identifier.citation | Latin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 32, n. 10, p. 1516-1521, 2013. | |
| dc.identifier.issn | 0326-2383 | |
| dc.identifier.lattes | 7927877224326837 | |
| dc.identifier.orcid | 0000-0003-3032-2556 | |
| dc.identifier.uri | http://hdl.handle.net/11449/111385 | |
| dc.identifier.wos | WOS:000331253000012 | |
| dc.language.iso | eng | |
| dc.publisher | Colegio Farmaceuticos Provincia de Buenos Aires | |
| dc.relation.ispartof | Latin American Journal of Pharmacy | |
| dc.relation.ispartofjcr | 0.401 | |
| dc.relation.ispartofsjr | 0,152 | |
| dc.rights.accessRights | Acesso restrito | |
| dc.source | Web of Science | |
| dc.subject | Cancer | en |
| dc.subject | Macrophages | en |
| dc.subject | Qualea multiflora | en |
| dc.title | Effect of Qualea multiflora on Macrophages and Tumour Cells | en |
| dc.type | Artigo | |
| dcterms.rightsHolder | Colegio Farmaceuticos Provincia De Buenos Aires | |
| unesp.author.lattes | 7927877224326837 | |
| unesp.author.orcid | 0000-0003-3032-2556[3] | |
| unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicente | pt |