DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

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dc.contributor.authorMoreli, Jusciele Brogin [UNESP]
dc.contributor.authorSantos, Janine Hertzog
dc.contributor.authorRocha, Clarissa Ribeiro
dc.contributor.authorDamasceno, Debora Cristina [UNESP]
dc.contributor.authorMorceli, Glilciane [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorBevilacqua, Estela
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNIEHS
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-03-18T15:55:37Z
dc.date.available2015-03-18T15:55:37Z
dc.date.issued2014-01-01
dc.description.abstractThe increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA.en
dc.description.affiliationSao Paulo State Univ, Grad Program Gynecol Obstet & Mastol, UNESP, Sao Paulo, Brazil
dc.description.affiliationNIEHS, Mol Carcinogenesis Lab, Durham, NC USA
dc.description.affiliationUniv Sao Paulo, Dept Microbiol, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynecol, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Grad Program Gynecol Obstet & Mastol, UNESP, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynecol, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 11/18240-2
dc.description.sponsorshipIdFAPESP: 11/13562-1
dc.description.sponsorshipIdFAPESP: 12/23296-0
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1155/2014/676758
dc.identifier.citationBiomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.
dc.identifier.doi10.1155/2014/676758
dc.identifier.fileWOS000340753200001.pdf
dc.identifier.fileWOS000340753200001.epub
dc.identifier.issn2314-6133
dc.identifier.lattes6758680388835078
dc.identifier.lattes0679387622604743
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/117237
dc.identifier.wosWOS:000340753200001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBiomed Research International
dc.relation.ispartofjcr2.583
dc.relation.ispartofsjr0,935
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleDNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environmenten
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes6758680388835078
unesp.author.lattes0679387622604743
unesp.author.orcid0000-0002-9227-832X[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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