Screening and determination of sulphonamide residues in bovine milk samples using a flow injection system

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dc.contributor.authorBedatty Fernandes, Flavio Cesar [UNESP]
dc.contributor.authorSilva, Aline Santana [UNESP]
dc.contributor.authorRufino, Jose Luiz [UNESP]
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:53:30Z
dc.date.available2015-03-18T15:53:30Z
dc.date.issued2015-01-01
dc.description.abstractA new, simple, rapid and sensitive flow injection spectrophotometric method was developed for the screening and determination of sulphonamides in bovine milk samples. The method is based on the condensation of sulphathiazole, sulphamethazine, and sulphadimethoxine with p-dimethylaminobenzaldehyde (p-DAB) in acid medium, in the presence of sodium dodecyl sulphate (SDS), producing a yellow compound (lambda(max) = 465 nm). Optimisation of the experimental parameters was performed using a multivariate methodology. The linear range was 90-500 mu g/L and the limits of detection and quantification were in the ranges 25-29 mu g/L and 84-88 mu g/L, respectively. The procedure was applied for the determination of sulphonamide antibiotics in bovine milk samples submitted to a prior extraction procedure based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) methodology. Recoveries of 60.5-70.5% were achieved for milk samples spiked with 0.09, 0.1, 0.2, and 0.3 mu g/g of each sulphonamide. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent309-315
dc.identifierhttp://dx.doi.org/10.1016/j.foodchem.2014.06.034
dc.identifier.citationFood Chemistry. Oxford: Elsevier Sci Ltd, v. 166, p. 309-315, 2015.
dc.identifier.doi10.1016/j.foodchem.2014.06.034
dc.identifier.issn0308-8146
dc.identifier.lattes3192125098361121
dc.identifier.lattes5978908591853524
dc.identifier.orcid0000-0003-0197-7369
dc.identifier.urihttp://hdl.handle.net/11449/116551
dc.identifier.wosWOS:000342654200042
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood Chemistry
dc.relation.ispartofjcr4.946
dc.relation.ispartofsjr1,793
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSulphonamidesen
dc.subjectp-Dimethylaminobenzaldehydeen
dc.subjectSpectrophotometryen
dc.subjectScreeningen
dc.subjectFlow injection analysisen
dc.subjectMilken
dc.titleScreening and determination of sulphonamide residues in bovine milk samples using a flow injection systemen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3192125098361121
unesp.author.lattes5978908591853524
unesp.author.orcid0000-0003-0197-7369[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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