In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold

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dc.contributor.authorMinarelli-Gaspar, A. M. [UNESP]
dc.contributor.authorSaska, S. [UNESP]
dc.contributor.authorJimenez, J.
dc.contributor.authorda Cunha, L. R. [UNESP]
dc.contributor.authorBolini, Paulo Domingos André [UNESP]
dc.contributor.authorLeal, C.
dc.contributor.authorMorejon-Alonso, L.
dc.contributor.authorCarrodeguas, R. G.
dc.contributor.authorLopez-Bravo, A.
dc.contributor.authorZavaglia, C. A. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHospital Provincial de Ávila
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidad de La Habana
dc.date.accessioned2014-05-20T13:46:49Z
dc.date.available2014-05-20T13:46:49Z
dc.date.issued2008-01-22
dc.description.abstractThe biological behavior of a new bioactive material composed of calcium-deficient hydroxyapatite, octacalcium phosphate, and beta-tricalcium phosphate was investigated by in vitro indirect and direct cytotoxicity, cell adhesion and proliferation tests, and by in vivo subcutaneous and bone implantation in rats. The results of the in vitro studies showed that the material is biocompatible and no cytotoxic. Slightly poorer initial cell adhesion and lower cell proliferation than in control was observed, which were attributed to the reactivity and roughness of the material surface, In vivo results showed that the material is biodegradable and bioactive in bone tissue, but only biocompatible and partially biodegradable in soft tissue.en
dc.description.affiliationDepto. de Morfologia Fac. de Odontologia de Araraquara UNESP, Rua Humaitá, 1680, 14.801-903 Araraquara-SP
dc.description.affiliationUnidad de Investigación Clínica y Biopatología Experimental Hospital Provincial de Ávila, C/ Jesús del Gran Poder, 42, 05003 Ávila
dc.description.affiliationDepto. de Eng. de Materiais Fac. de Eng. Mecânica UNICAMP, R. Mendeleiev s/n, CP 6122, 13.083-970 Campinas-SP
dc.description.affiliationCentro de Biomateriales Universidad de La Habana, Ave. Universidad s/n e/ G y Ronda, 10400 La Habana
dc.description.affiliationUnespDepto. de Morfologia Fac. de Odontologia de Araraquara UNESP, Rua Humaitá, 1680, 14.801-903 Araraquara-SP
dc.format.extent1127-1130
dc.identifierhttp://www.scientific.net/KEM.361-363.1127
dc.identifier.citationKey Engineering Materials, v. 361-363 II, p. 1127-1130.
dc.identifier.doi10.4028/www.scientific.net/KEM.361-363.1127
dc.identifier.issn1013-9826
dc.identifier.lattes1393640448238401
dc.identifier.scopus2-s2.0-38149111869
dc.identifier.urihttp://hdl.handle.net/11449/130424
dc.identifier.wosWOS:000253480200278
dc.language.isoeng
dc.publisherTrans Tech Publications Ltd
dc.relation.ispartofKey Engineering Materials
dc.relation.ispartofsjr0,180
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectβ-tricalcium phosphate
dc.subjectCalcium deficient hydroxiapatite
dc.subjectIn vitro
dc.subjectIn vivo
dc.subjectOctacalcium phosphate
dc.subjectBioactivity
dc.subjectBone
dc.subjectCalcium phosphate
dc.subjectCell proliferation
dc.subjectCytotoxicity
dc.subjectHydroxyapatite
dc.subjectBiomaterials
dc.titleIn vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffolden
dc.typeTrabalho apresentado em evento
dcterms.licensehttp://www.ttp.net/Downloads.html
dcterms.rightsHolderTrans Tech Publications Ltd
unesp.author.lattes1393640448238401[5]
unesp.author.lattes8379925533335630[1]
unesp.author.orcid0000-0002-7168-9971[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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