Autonomic control of heart rate during orthostasis and the importance of orthostatic-tachycardia in the snake Python molurus

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dc.contributor.authorArmelin, Vinicius Araujo
dc.contributor.authorSilva Braga, Victor Hugo da [UNESP]
dc.contributor.authorAbe, Augusto Shinya [UNESP]
dc.contributor.authorRantin, Francisco Tadeu
dc.contributor.authorFlorindo, Luiz Henrique [UNESP]
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionNatl Inst Sci & Technology Comparat Physiol INCT
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:52:59Z
dc.date.available2015-03-18T15:52:59Z
dc.date.issued2014-10-01
dc.description.abstractOrthostasis dramatically influences the hemodynamics of terrestrial vertebrates, especially large and elongated animals such as snakes. When these animals assume a vertical orientation, gravity tends to reduce venous return, cardiac filling, cardiac output and blood pressure to the anterior regions of the body. The hypotension triggers physiological responses, which generally include vasomotor adjustments and tachycardia to normalize blood pressure. While some studies have focused on understanding the regulation of these vasomotor adjustments in ectothermic vertebrates, little is known about regulation and the importance of heart rate in these animals during orthostasis. We acquired heart rate and carotid pulse pressure (P (PC)) in pythons in their horizontal position, and during 30 and 60A degrees inclinations while the animals were either untreated (control) or upon muscarinic cholinoceptor blockade and a double autonomic blockade. Double autonomic blockade completely eradicated the orthostatic-tachycardia, and without this adjustment, the P (PC) reduction caused by the tilts became higher than that which was observed in untreated animals. On the other hand, post-inclinatory vasomotor adjustments appeared to be of negligible importance in counterbalancing the hemodynamic effects of gravity. Finally, calculations of cardiac autonomic tones at each position revealed that the orthostatic-tachycardia is almost completely elicited by a withdrawal of vagal drive.en
dc.description.affiliationFed Univ Sao Carlos UFSCar, Dept Physiol Sci, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationNatl Inst Sci & Technology Comparat Physiol INCT, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Dept Bot & Zool, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Dept Zool, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Bot & Zool, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Zool, BR-13506900 Rio Claro, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent903-912
dc.identifierhttp://dx.doi.org/10.1007/s00360-014-0841-0
dc.identifier.citationJournal Of Comparative Physiology B-biochemical Systemic And Environmental Physiology. Heidelberg: Springer Heidelberg, v. 184, n. 7, p. 903-912, 2014.
dc.identifier.doi10.1007/s00360-014-0841-0
dc.identifier.issn0174-1578
dc.identifier.lattes2797832406818407
dc.identifier.urihttp://hdl.handle.net/11449/116261
dc.identifier.wosWOS:000342431500008
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal Of Comparative Physiology B-biochemical Systemic And Environmental Physiology
dc.relation.ispartofjcr2.517
dc.relation.ispartofsjr0,952
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAutonomic controlen
dc.subjectGravityen
dc.subjectHeart rateen
dc.subjectOrthostasisen
dc.subjectPython molurusen
dc.subjectSnakeen
dc.titleAutonomic control of heart rate during orthostasis and the importance of orthostatic-tachycardia in the snake Python molurusen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes2797832406818407
unesp.author.lattes8776757457144680[3]
unesp.author.orcid0000-0002-6765-8726[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Zoologia e Botânica - IBILCE
Artigos - Zoologia - IBRC