Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens
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Data
2023-01-01
Autores
Souza, Jéssica A. de M.
Gubiani, Juliana R.
de Siqueira, Kátia A.
de Camargo, Maria J.
Garcez, Walmir S.
de Sousa, Paulo T.
Soares, Marcos A.
Araújo, Ângela R. [UNESP]
Nunes, Emanuel V. dos S. [UNESP]
Vieira, Lucas C. C.
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Resumo
Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-10,11-dihydroxy-5,5,8-trimethyl-4-oxocycloundeca-1,8-diene-1-carbaldehyde (1) and four known compounds: 5-methylmellein (2), sclerone (3), daldinone A (4), and lasiodiplodin (5). All compounds were identified using spectroscopic methods, and 1 was corroborated with mass spectrometry, while the known compounds were compared with data in the literature. The relative configuration of compound 1 was determined based on theoretical conformational studies as well as the J experimental values between the hydroxymethyne hydrogens. The antimicrobial activity of the compounds was evaluated. Promising results were obtained for compounds 2, 4, and 5 since they inhibited the bacterium Pseudomonas aeruginosa, an opportunistic pathogen, suggesting the potential of these microorganisms as a source of new antibacterial agents.
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antibacterial activity, Endophytic fungi, Vochysia divergens
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Natural Product Research.