Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens

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dc.contributor.authorSouza, Jéssica A. de M.
dc.contributor.authorGubiani, Juliana R.
dc.contributor.authorde Siqueira, Kátia A.
dc.contributor.authorde Camargo, Maria J.
dc.contributor.authorGarcez, Walmir S.
dc.contributor.authorde Sousa, Paulo T.
dc.contributor.authorSoares, Marcos A.
dc.contributor.authorAraújo, Ângela R. [UNESP]
dc.contributor.authorNunes, Emanuel V. dos S. [UNESP]
dc.contributor.authorVieira, Lucas C. C.
dc.contributor.authorSampaio, Olívia M.
dc.contributor.authorGoulart, Letícia S.
dc.contributor.authorBiasetto, Carolina R. [UNESP]
dc.contributor.authorde Menezes, Orivaldo T.
dc.contributor.authorde Oliveira, Camila M.
dc.contributor.authorNogueira, Cláudio R.
dc.contributor.authorPinto, Luciano da S.
dc.contributor.authorTeles, Helder L.
dc.contributor.institutionFederal University of Mato Grosso
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionMilitary College of Campo Grande
dc.contributor.institutionFederal University of Mato Grosso do Sul
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Rondonópolis
dc.contributor.institutionFederal University of Amazonas
dc.contributor.institutionFederal University of Grande Dourados
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2023-07-29T13:53:50Z
dc.date.available2023-07-29T13:53:50Z
dc.date.issued2023-01-01
dc.description.abstractInvestigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-10,11-dihydroxy-5,5,8-trimethyl-4-oxocycloundeca-1,8-diene-1-carbaldehyde (1) and four known compounds: 5-methylmellein (2), sclerone (3), daldinone A (4), and lasiodiplodin (5). All compounds were identified using spectroscopic methods, and 1 was corroborated with mass spectrometry, while the known compounds were compared with data in the literature. The relative configuration of compound 1 was determined based on theoretical conformational studies as well as the J experimental values between the hydroxymethyne hydrogens. The antimicrobial activity of the compounds was evaluated. Promising results were obtained for compounds 2, 4, and 5 since they inhibited the bacterium Pseudomonas aeruginosa, an opportunistic pathogen, suggesting the potential of these microorganisms as a source of new antibacterial agents.en
dc.description.affiliationDepartment of Chemistry Federal University of Mato Grosso
dc.description.affiliationInstitute of Chemistry of São Carlos São Paulo University
dc.description.affiliationInstitute of Biosciences Federal University of Mato Grosso
dc.description.affiliationMilitary College of Campo Grande
dc.description.affiliationInstitute of Chemistry Federal University of Mato Grosso do Sul
dc.description.affiliationInstitute of Chemistry Department of Biochemistry and Organic Chemistry NuBBE São Paulo State University
dc.description.affiliationFaculty of Health Sciences Federal University of Rondonópolis
dc.description.affiliationInstitute of Exact Sciences and Technology Federal University of Amazonas
dc.description.affiliationInstitute of Exact and Natural Sciences Federal University of Rondonópolis
dc.description.affiliationFaculty of Exact Sciences and Technology Federal University of Grande Dourados
dc.description.affiliationDepartment of Chemistry Federal University of São Carlos
dc.description.affiliationUnespInstitute of Chemistry Department of Biochemistry and Organic Chemistry NuBBE São Paulo State University
dc.identifierhttp://dx.doi.org/10.1080/14786419.2023.2208723
dc.identifier.citationNatural Product Research.
dc.identifier.doi10.1080/14786419.2023.2208723
dc.identifier.issn1478-6427
dc.identifier.issn1478-6419
dc.identifier.scopus2-s2.0-85158088949
dc.identifier.urihttp://hdl.handle.net/11449/248790
dc.language.isoeng
dc.relation.ispartofNatural Product Research
dc.sourceScopus
dc.subjectantibacterial activity
dc.subjectEndophytic fungi
dc.subjectVochysia divergens
dc.titleAntimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergensen
dc.typeArtigo
unesp.author.orcid0000-0002-0930-3628[2]
unesp.author.orcid0000-0002-6292-5530[9]
unesp.author.orcid0000-0003-2267-4754[16]
unesp.author.orcid0000-0002-5362-2423[17]
unesp.author.orcid0000-0001-9341-4605[18]

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