Electrospun PHBV nanofiber containing Tea Tree Oil: physicochemical and antimicrobial activity
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Data
2023-01-01
Autores
dos Santos, Verônica Ribeiro
Vera, Samara Domingues
de Cena, Gabrielle Lupeti
Silva, Adrielle de Paula
Lemes, Ana Paula
da Conceição, Kátia
Tada, Dayane Batista
Borges, Alexandre Luiz Souto [UNESP]
Trichês, Eliandra de Sousa
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Resumo
Aiming to produce an antimicrobial dressing for wound healing applications, in this work Tea Tree oil (TTO) was incorporated into PHBV nanofibers by absorption. It was observed increase in the nanofiber diameter due to 5% TTO absorption efficiency, which also led to a 54% decrease in the contact angle. The releasing assay indicates a 6.8% oil release in the first 24 h – being probably the oil deposited at the polymer surface – followed by a minimal release at 48 h. The set of antimicrobial assays performed suggests the incorporation of TTO optimized the antimicrobial activity of the polymer for E. coli and C. albicans, while against S. aureus no significant difference was observed. The MTT assay showed no cytotoxicity of PHBV, but the incubation of L929 fibroblast cells with PHBV-TTO reduced cell viability. Overall, the PHBV nanofibers containing TTO present great potential as an antimicrobial dressing.
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antimicrobial activity, nanofiber, PHBV, tea tree oil, wound healing
Como citar
Polimeros, v. 33, n. 1, 2023.