Primary Tracheal Squamous Cells Carcinoma in a Dog

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dc.contributor.authorde Lima, Bruno Medolago [UNESP]
dc.contributor.authorde Assis, Juliana Viegas
dc.contributor.authorPellissari, Maria Cecília Clarindo [UNESP]
dc.contributor.authorManske, Luiza Raasch [UNESP]
dc.contributor.authorRoca, Tifany da Silva Sato [UNESP]
dc.contributor.authorde Alcântara, Brenda Mendonça [UNESP]
dc.contributor.authorSantos, Natália da Silva
dc.contributor.authorPeres, Marina Lombardi
dc.contributor.authorde Andrade, Alexandre Lima [UNESP]
dc.contributor.authorMachado, Gisele Fabrino [UNESP]
dc.contributor.authorRozza, Daniela Bernadete [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Brasil-Campus Fernandópolis
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionAutonomous veterinary
dc.date.accessioned2023-07-29T13:31:52Z
dc.date.available2023-07-29T13:31:52Z
dc.date.issued2022-01-01
dc.description.abstractPrimary tracheal neoplasms are uncommon and poorly documented in veterinary medicine, being most frequently reported in domestic cats. Squamous cell carcinoma (SCC) is a malignant neoplasm that originates from the stratified squamous epithelium, considered one of the most common skin neoplasms in dogs and cats. This paper aims to report the anatomopathological and immunohistochemical findings of a clinical case of primary SCC in the trachea of a female Schnauzer canine, attended at the Veterinary Hospital Luiz Quintiliano de Oliveira of the Faculty of Veterinary Medicine of Araçatuba (FMVA – UNESP), presenting clinical signs such as choking, coughing and dyspnea for 1 month. The tracheal portion affected by the neoplasm was sent to the Veterinary Pathology department of the FMVA after surgical excision. Fragments of the neoplasm were collected and fixed in 10% formaldehyde for further histopathological and immunohistochemical analysis. Microscopically, the neoplasm was well differentiated, being characterized by the presence of keratin pearls, low degree of pleomorphism and rare mitotic figures. In the immunohistochemical analysis, there was immunoexpression of anti-cytokeratin antibodies AE1AE3, 34BE12, CK14 and CK5/6, confirming the diagnosis of squamous cell carcinoma. In about 30% of the cells there was immunostaining for Ki67 antibodies, justifying the low mitotic index of tumor cells and the few images of mitosis seen. Due to the rare occurrence of primary tracheal SCC in dogs, the use of diversified diagnostic techniques is important in order to better understand the biological behavior of this neoplasm in unusual anatomical locations.en
dc.description.affiliationHospital Veterinário Luiz Quintiliano de Oliveira FMVA-UNESP, SP
dc.description.affiliationUniversidade Brasil-Campus Fernandópolis, SP
dc.description.affiliationFMVZ-USP, SP
dc.description.affiliationFaculdade de Medicina Veterinária FMVA-UNESP, SP
dc.description.affiliationFaculdade de Ciências Agrárias e Veterinárias FCAV-UNESP, SP
dc.description.affiliationAutonomous veterinary, SP
dc.description.affiliationDepartment of Clinical Surgery and Animal Reproduction FMVA-UNESP, SP
dc.description.affiliationUnespHospital Veterinário Luiz Quintiliano de Oliveira FMVA-UNESP, SP
dc.description.affiliationUnespFaculdade de Medicina Veterinária FMVA-UNESP, SP
dc.description.affiliationUnespFaculdade de Ciências Agrárias e Veterinárias FCAV-UNESP, SP
dc.description.affiliationUnespDepartment of Clinical Surgery and Animal Reproduction FMVA-UNESP, SP
dc.format.extent147-152
dc.identifierhttp://dx.doi.org/10.24070/bjvp.1983-0246.v15i3p147-152
dc.identifier.citationBrazilian Journal of Veterinary Pathology, v. 15, n. 3, p. 147-152, 2022.
dc.identifier.doi10.24070/bjvp.1983-0246.v15i3p147-152
dc.identifier.issn1983-0246
dc.identifier.scopus2-s2.0-85143591485
dc.identifier.urihttp://hdl.handle.net/11449/248005
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Veterinary Pathology
dc.sourceScopus
dc.subjectcanine
dc.subjecthistopathology
dc.subjectneoplasm
dc.titlePrimary Tracheal Squamous Cells Carcinoma in a Dogen
dc.typeArtigo

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Artigos - Clínica, Cirurgia e Reprodução Animal - FMVA