Departamento de Pediatria

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Metabolismo (lipídios e proteínas) e histopatologia do cérebro de ratos recém nascidos, jovens e adultos, submetidos a desnutrição proteico calórica, tipo marasmo
(1977-12-01) Kfouri, J. R. N. [UNESP]; Trindade, Cleide Enoir Petean [UNESP]; Nóbrega, Fernando José de [UNESP]; Universidade Estadual Paulista (Unesp)
Brains of Wistar male rats (newborns, youngs and adults) submitted to protein-calorie deprivation for different periods (27, 33 and 60 days) were studied histologically and biochemically (protein and lipids contents). Lower levels of lipid, particularly among young rats, were observed in all groups. The protein levels were also significantly lower in the newborns, only slightly diminished in the youngs and not altered in the adults. On the other hand the histological study made in all groups did not show any qualitative modifications. The authors concluded that the protein-calorie deprivation affects the brain composition markedly in the earlier periods of life when the developing rate is greater. This could result in irreversible brain damage.
Desnutrição fetal experimental em ratos: efeitos sobre o peso corporal, o peso cerebral, o teor de lipídios totais, proteínas e colesterol no cérebro
(1978-01-01) Tonete, S. de Souza Queiroz [UNESP]; Coelho, Cláudio Antônio Rabello [UNESP]; Nóbrega, F. S. de [UNESP]; Universidade Estadual Paulista (Unesp)
A new acro-renal syndrome
(Soc Biol Chile, 1981-01-01) Freiremaia, D. V.; Trindade, CEP; Sughihara, C. Y.; Freiremaia, N.; Universidade Estadual Paulista (Unesp); Universidade Federal do Paraná (UFPR)
CALCIUM, PHOSPHORUS AND MAGNESIUM-METABOLISM IN RATS SUBMITTED TO PROTEIN-CALORIE DEPRIVATION IN DIFFERENT GESTATIONAL PERIODS
(Archivos Latinoamericanos Nutricion, 1982-01-01) Sartor, MEA; Denobrega, F. J.; Tonete, SSQ; Trinidade, CEP; Curi, P. R.; Universidade Estadual Paulista (Unesp)
INTRAUTERINE MALNUTRITION IN RATS .1. REPERCUSSION IN BODY-WEIGHT GAIN, DURATION OF PREGNANCY AND NUMBER OF OFFSPRING
(Archivos Latinoamericanos Nutricion, 1983-01-01) Tonete, SDQ; Denobrega, F. J.; Curi, P. R.; Trindade, CEP; Artor, MEA; Demoura, ECV; Universidade Estadual Paulista (Unesp)
INTRAUTERINE MALNUTRITION IN RATS .2. BODY-WEIGHT AND MORTALITY OF OFFSPRING
(Archivos Latinoamericanos Nutricion, 1983-01-01) Tonete, SDQ; Denobrega, F. J.; Sartor, MEA; Trindade, CEP; Lopez, F. A.; Curi, P. R.; Universidade Estadual Paulista (Unesp)
Saúde materno-infantil: visão crítica dos determinantes e dos programas assistenciais
(Universidade de São Paulo (USP), Faculdade de Saúde Pública, 1983-06-01) Oliveira, Luiz Roberto de [UNESP]; Rizzato, Agueda Beatriz Pires [UNESP]; Magaldi, Cecília [UNESP]; Universidade Estadual Paulista (Unesp)
Discute-se a determinação social da saúde materno-infantil nas Américas, a partir de inúmeras publicações e recomendações oficiais. Observou-se que nem todos os estudos valorizam apropriadamente as variáveis sociais e que muitos deles as consideram no mesmo nível de importância das variáveis biológicas. Como conseqüência, a compreensão final dos achados fica prejudicada e as conclusões e recomendações extraídas ficam longe de tocar a raiz dos problemas. Diferentes variáveis sociais (como escolaridade materna ou assistência médica) encontram-se freqüentemente associadas com variáveis biológicas (como peso ao nascer ou estado nutricional). Esta associação, no entanto, pode não representar uma relação causai, mas tão somente a ocorrência simultânea de características pertencentes a uma única classe social. Reitera-se a necessidade de estudos que reconheçam as classes sociais e analisem os resultados sobre saúde materno-infantil em relação às mesmas. Estes estudos provavelmente evidenciarão a importância social da saúde materno-infantil e evitarão as habituais diretrizes e recomendações restritas ao plano puramente técnico.
Zinc in different periods of pregnancy: A study on pregnant women of high and low socio-economic levels.
(1984-01-01) Trindade, Cleide Enoir Petean [UNESP]; de Souza Queiroz Tonete, Suzana [UNESP]; Sartori, Maria Eneida Aiello [UNESP]; de Nobrega, Fernando José; Rudge, Marilza Vieira Cunha [UNESP]; Tonete, José Teodore Veneziano; Filho, Sebastiao Camargo Schimidt; Universidade Estadual Paulista (UNESP)
We have measured zinc in the serum of pregnant and non-pregnant women classified in two socio economic levels, high socio-economic level pregnant and non-pregnant women attending a private office and low socio-economic level pregnant and nonpregnant women either attending our hospital, belonging to a social welfare or not. The samples in the pregnant women were collected in the first, second and third trimesters of pregnancy. The socio-economic condition was proved to be important when comparing both groups of pregnant women. Such differences had already been remarked in the non-pregnant women group where the serum concentration was statistically greater at a higher socio-economic condition. Also both groups had different behaviours during the pregnancy. The women having a high socio-economic condition did not present any remarkable difference during the pregnancy whereas the low socio-economic condition ones, showed in the third trimester, zinc levels significantly lower than in the second trimester of pregnancy. © Gordon and Breach Science Publishers, Inc., 1984
Serum zinc in mothers and from cord blood of appropriate birth-weight full term and preterm newborn infants, and of low-birth-weight full term infants
(1984-01-01) Trindade, Cleide Enoir Petean [UNESP]; Sartor, Maria Eneida Aiello [UNESP]; de Souza Queiroz Tonete, Suzana [UNESP]; Curi, Paulo Roberto [UNESP]; Zuliani, Antonio [UNESP]; de Nòbrega, Fernando José; Rudge, Marilza Vieira Cunha [UNESP]; Universidade Estadual Paulista (UNESP)
In order to prove the zinc behaviour in prematurity and in intrauterine malnutrition we have measured this element in mother's serum soon after parturition and from cord blood of their infants—appropriate and low-birth weight full term infants and appropriate birth weight preterm infants. We have also evidenced serum zinc from cord blood of appropriate birth-weight full term and preterm newborn infants, and of low-birth-weight full term newborn infants. The maternal groups being compared to one another didn't show any difference statistically significant; the same happened to the cord serum in newborn groups. The comparisons in the concentrations of maternal serum and newborn infants in each group showed that for appropriate and low-birth-weight full term infants as for appropriate birth-weight preterm infants the cord blood determination averages were higher than the corresponding mothers. We concluded that neither the prematurity nor the fetal growth delay interfere in the maternal zinc levels and in the newborn infants at birth. © Gordon and Breach Science Publishers, Inc., 1984
Immunological assessment and its predictive role in malnourished infants with diarrhoea and/or systemic infections
(1988-04-01) Maffei, Helga V.L.; Monteiro, Cassia M.C.; Iwasso, Maria T.R.; Mota, Norma G.S.; Cun, Paulo R.; Faculty of Medicine of Botucatu
The Immune capacity of 47 marasmic 1-12 months old ill infants with weights below 75 per cent of Brazilian standards and of 12 well-nourished healthy controls was studied, by measuring: the absolute and relative T and B lymphocyte subpopulatioits, the blastogenic response to phytohaemagglutinin (PHA), expressed as stimulation index (SI), and the delayed hypersensitivity skin test with PHA. Eight (17 per cent) of the malnourished infants died and results were evaluated with respect to ultimate outcome. In addition a discriminant analysis was retrospectively applied to the immunological data of the two groups of malnourished infants.Both groups of malnourished infants presented significantly lower values than the control group for all measurements, although not very evident for B lymphocytes. The immunodepression was more intense for the infants who died than for those who survived, as shown by significantly lower values for the SI, the skin test, and by the discriminant analysis. The discriminant analysis led to a linear predictive model which accurately classified 85 per cent of the survivors and 100 per cent of those who died. It was con cluded that immunological parameters may be useful to select prospectively those infants who need a different therapeutic approach because of their high risk of mortality. © 1988 Oxford University Press.
EFFECTS OF EUGLYCEMIC HYPERINSULINEMIA ON NEONATAL CANINE HEPATIC AND MUSCLE METABOLISM
(Williams & Wilkins, 1989-02-01) Kliegman, R.; Trindade, C.; Huang, M.; Hulman, S.; Universidade Estadual Paulista (Unesp)
POPULATION-BASED INCIDENCE OF IDDM IN THE STATE OF SAO-PAULO, BRAZIL
(Amer Diabetes Assoc, 1993-05-01) Ferreira, SRG; Franco, L. J.; Vivolo, M. A.; Negrato, C. A.; Simoes, ACP; Ventureli, C. R.; Universidade Estadual Paulista (Unesp)
OBJECTIVE- To study the incidence of IDDM among children, infants to 14 yr of age, in the state of São Paulo, Brazil, 1987-1991.RESEARCH DESIGN AND METHODS - A prospective population-based register was established, using physician reports of newly diagnosed IDDM patients < 15 yr of age as the primary source of case identification and school surveys as the main secondary source. Data were collected according to the methods recommended by the Diabetes Epidemiology Research International group.RESULTS - Case ascertainment was estimated at 95.0, 92.8, and 98.8% complete for each of the three cities studied. The average annual IDDM incidence was 7.6/100,000 inhabitants (95% confidence interval, 5.6-9.7). We found a higher incidence rate in girls than boys.CONCLUSIONS - the incidence of childhood IDDM in a tropical region in South America (São Paulo, Brazil) is in the middle incidence range observed in developed countries throughout the world. Increased incidence of IDDM in girls compared with boys will be tested by the ongoing Brazilian incidence study being developed in 18 other centers across the country.
Avaliação do desenvolvimento afetivo-social do adolescente na faixa etária dos 15 aos 18 anos. Estudo com adolescentes do município de Botucatu, SP - Aspectos da sexualidade
(Jornal De Pediatria, 1994) Goldberg, T. B. [UNESP]; Jaehn, S. M.; Campana, A de P; Kfouri, J. R.; Simões, A. C.; Curi, P. R.; Universidade Estadual Paulista (Unesp)
The authors present data obtained from the analysis of a questionnaire regarding sexuality among 1,437 adolescent students in the Botucatu municipal district. The student's age varied from 15 to 19 years. The results demonstrate the evolving characteristics of the student's sexuality and suggest that sexual orientation and guidance should be part of the child and adolescent educational process. The authors pointed out that the members of Health care team should stimulate the discussion of sexuality while providing medical advice.
História clínica e alimentar de crianças atendidas em ambulatório de gastroenterologia pediátrica (GEP) com constipação intestinal crônica funcional (CICF) e suas possíveis complicações
(Jornal De Pediatria, 1994) Maffei, H. V. [UNESP]; Moreira, F. L.; Kissimoto, M.; Chaves, S. M.; Faro, S. E.; Aleixo, A. M.; Universidade Estadual Paulista (Unesp)
In order to better understand the natural history of chronic functional constipation, a questionnaire was applied to 163 children and infants, before beginning standardized treatment. Median age (range) at start was 3 mo(0-108 mo) but age at arrival at the Pediatric Gastroenterology Unit was 53 mo(2-146 mo). In 62.4% of the cases symptoms began before or up to 3 mo after cow's milk introduction and rarely around (-/+ 6 mo) toilet training. Possible complications appeared progressively, often at preschool or school age or as the first noticeable manifestation: recurrent abdominal pain (61.1%), fecal soiling (45.4%), fecal blood (35%), enuresis (23.3%), vomiting (19%), urinary infection (17.9%), urinary retention (8.6%). Abdominal distension was rarely detected on physical examination and was usually discrete. In conclusion, children attended in Botucatu begin their constipation at an early age, frequently associated with weaning,and important complications may ensue along years. This evolution should be avoided by prevention and early treatment of constipation.
Assessment of gut intraepithelial lymphocytes during late gestation and the neonatal period
(1994-01-01) Machado, Claudia S. M.; Rodrigues, M. A.; Maffei, H. V.
Intraepithelial lymphocyte counts (IEL % enterocytes) were diceal mucosa of 39 neonates, aged from birth to 28 days. Cor-Neonates relations between IEL counts and developmental factors, namely gestational age, birth weight and intrauterine growth, as well as neonatal infections or feeding state were performed. No significant differences were observed among neonates grouped according to birth weight, intrauterine growth or neonatal infections. The pattern of feeding, however was associated with significantly higher IEL counts (p < 0.02) in the ileum in oral/enterally fed neonates than in the unfed or parenterally fed. Full-term neonates also had higher counts in the ileum (p < 0.02). In this group, oral/enterally fed neonates had the higher values. Thus, besides in utero development, the pattern of feeding might be considered as an important modulating factor on IEL postnatal expansion. © 1994 S. Karger AG, Basel.
SURFACTANTE COMO TERAPEUTICA DA SINDROME DE DESCONFORTO RESPIRATORIO DO RECEM-NASCIDO DE PRE-TERMO
(1994-12-01) Trindade, C. E P [UNESP]; Universidade Estadual Paulista (Unesp)
Terapêutica com doses profiláticas de sulfato ferroso como medida de intervenção no combate à carência de ferro em crianças atendidas em unidades básicas de saúde
(Universidade de São Paulo (USP), Faculdade de Saúde Pública, 1994-12-01) Torres, Marco A. A.; Sato, Kasue; Juliano, Yara; Queiroz, Suzana S. [UNESP]; Secretaria de Estado da Saúde de São Paulo Núcleo de Nutrição do Centro de Referência de Saúde da Mulher, Nutrição, Alimentação e Desenvolvimento Infantil Centro de Apoio ao Desenvolvimento da Atenção Integral à Saúde; Escola Paulista de Medicina Departamento de Medicina Preventiva; Universidade Estadual Paulista (Unesp)
Objetivou-se testar a terapêutica com doses profiláticas de sulfato ferroso no combate à anemia carencial ferropriva, em 620 crianças de 4 a 36 meses de idade, atendidas em duas unidades de saúde do Município de São Paulo, Brasil. As crianças foram submetidas a coleta de sangue para dosagem de hemoglobina. em seguida, foi prescrito dosagem de 12 mg/dia de ferro elementar, por 30 dias. Observou-se que 25% dos menores de 6 meses apresentaram níveis de hemoglobina inferiores a 11,0 g/dl. As maiores ocorrências de anemia foram detectadas entre os 9 e 23 meses de idade (50,0%). Decorrido o prazo, apenas 37,4% das crianças com anemia e 52,4% das não anêmicas retornaram para reavaliação. Das 299 que foram reavaliadas, somente 157 (52,5%) receberam a medicação corretamente. A freqüência de hemoglobinas inferiores a 9,5 g/dl caiu de 17,1% no início, para 8,1% ao final da intervenção. Por outro lado, o percentual de crianças com hemoglobinas superiores a 12,0 g/dl subiu de 13,4%, para 33,4%. As que receberam a suplementação férrica de forma correta registraram queda nos índices de anemia sensivelmente maior que a observada naquelas suplementadas de forma incorreta. Concluiu-se que a terapêutica com doses profiláticas de sulfato ferroso, apesar de se mostrar eficiente na recuperação dos níveis de hemoglobina, apresenta sérios entraves do ponto de vista operacional.
Rim esponja medular, litíase, hipercalciúria e hiperuricosúria em criança. Relato de um caso e evolução
(Jornal De Pediatria, 1996) Macedo, C. S. [UNESP]; Riyuzo, M. C.; Bastos, H. D.; Morcelli, J.; Universidade Estadual Paulista (Unesp)
The medullary sponge kidney is rare in children and may present it self with hematuria and nephrolithiasis. We report a case of medullary sponge kidney in a child with nephrolithiasis, hypercalciuria, hyperuricosuria and prolonged treatment which avoided the recurrence of nephrolithiasis.
Relação entre área do braço, área do músculo, área de gordura do braço e a menarca em adolescentes do município de Botucatu
(Jornal De Pediatria, 1996) Goldberg, T. B. [UNESP]; Colli, A. S.; Curi, P. R.; Universidade Estadual Paulista (Unesp)
The authors show the relations among arm circumference, arm muscle and arm fat areas with or without menarche, by carrying out an anthropometric study in 717 adolescents in the municipality of Botucatu. It must be emphasized that those adolescents who had already menstruated presented significantly higher nutritional indicators than those who had not menstruated yet. There was an increase in fat tissue and lean body mass in those adolescents who had already menstruated. Body changes might be expressed by calculating muscle and arm fat areas using triceps skinfold and arm circumference.
Evolução antropométrica de crianças hospitalizadas com diarréia persistente e desnutrição grave, submetidas a suporte nutricional
(Jornal De Pediatria, 1996) Moreira, F. L. [UNESP]; Padovani, C. R.; Maffei, H. V.; Universidade Estadual Paulista (Unesp)
In order to estimate the nutritional rehabilitation (NR) during admission of malnourished children with persistent diarrhea (PD) receiving standardized nutritional support (NS), we prospectively evaluated the weight, height, head circumference and arm measurements (AM) of 20 children, 19 below 1 year, admitted to the ward with weigh/age -2.89 to -5.21 standard deviation. Four infants comprised the death group (DG) and 16 survived (SG). The SG was separated, according to initial weight behavior, into weight gain (WG) or weight loss (WL). Compared to SG at admission, DG only had lower AM and more metabolic-infectious alterations (p<05). The survivors presented NR but this was evident for WL only when considering the minimum weight. DG received less calories than SG and weight loss during the pre-death period was higher than for WL (p<05). It was concluded that very altered AM, severe metabolic-infectious insults, low caloric input and high weight loss velocity are associated to bad prognosis; severely malnourished infants with PD began NR during hospitalization while receiving adequate NS, but minimum weight must be considered for this evaluation; AM must be obtained at admission, due to its prognostic value, and adequate NS as well as anthropometric follow-up during the hospital stay are essential.

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