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COMPARISON OF THE ANTIFUNGAL ACTIVITY OF BLACK, WHITE, AND GREEN TEA KOMBUCHA EXTRACTS AGAINST DERMATOPHYTE FUNGI

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dc.contributor.authorBrizzotti-Mazuchi, Natalia Seron
dc.contributor.authorLemes, Thiago Henrique [UNESP]
dc.contributor.authorSiqueira, João Paulo Zen
dc.contributor.authorRibeiro-Marques, Mariela Domiciano
dc.contributor.authorMaschio-Lima, Taiza [UNESP]
dc.contributor.authorPolaquini, Carlos Roberto [UNESP]
dc.contributor.authorNascentes, Julyanna Andrade Silva [UNESP]
dc.contributor.authorde Assis, Leticia Ribeiro [UNESP]
dc.contributor.authordos Santos Theodoro, Reinaldo [UNESP]
dc.contributor.authorRegasini, Luis Octavio [UNESP]
dc.contributor.authorPaziani, Mario Henrique
dc.contributor.authorKress, Márcia Regina von Zeska
dc.contributor.authorCastilho, Elza Maria
dc.contributor.authorde Almeida, Margarete Teresa Gottardo
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2025-04-29T18:50:25Z
dc.date.issued2024-01-01
dc.description.abstractKombucha is obtained by fermentation of tea and sugar by bacteria and yeast. This beverage has several beneficial effects, including antimicrobial activity. The objective of this study was to evaluate the antifungal activity of Kombucha extracts against dermatomycosis-causing fungi. Different types of Kombucha (black, white, green tea) and times of fermentation (10, 20, 30 days) were evaluated. Kombuchas were filtered, and extracts obtained by liquid-liquid extraction with ethyl acetate. Minimum inhibitory concentrations (MIC) were determined against clinical isolates of dermatophytes Trichophyton rubrum and T. mentagrophytes by broth microdilution. Toxicity tests and high-performance liquid chromatography (HPLC) were also performed. MIC ranged from 62.5–2000 μg/mL. Green tea Kombucha and 10-days fermentation extracts showed the best results. Toxicity was observed only for white tea Kombucha. Despite the chromatographic profiles, further studies are needed to characterize the active molecules. However, Kombucha extracts may constitute a viable alternative for new treatment strategies against dermatomycosis.en
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), 5416 Brigadeiro Faria Lima Ave., São José do Rio Preto
dc.description.affiliationUniversidade Estadual Paulista (Unesp) Instituto de Biociências Letras e Ciências Exatas, 2265 Cristóvão Colombo St., São José do Rio Preto
dc.description.affiliationUniversidade de São Paulo (USP) Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Café Ave., Ribeirão Preto
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp) Instituto de Biociências Letras e Ciências Exatas, 2265 Cristóvão Colombo St., São José do Rio Preto
dc.identifierhttp://dx.doi.org/10.55251/jmbfs.5899
dc.identifier.citationJournal of Microbiology, Biotechnology and Food Sciences, v. 14, n. 1, 2024.
dc.identifier.doi10.55251/jmbfs.5899
dc.identifier.issn1338-5178
dc.identifier.scopus2-s2.0-85200637076
dc.identifier.urihttps://hdl.handle.net/11449/300723
dc.language.isoeng
dc.relation.ispartofJournal of Microbiology, Biotechnology and Food Sciences
dc.sourceScopus
dc.subjectAntifungal susceptibility testing
dc.subjectDermatophytosis
dc.subjectKombucha
dc.subjectLiquid-liquid extraction
dc.subjectTrichophyton mentagrophytes
dc.subjectTrichophyton rubrum
dc.titleCOMPARISON OF THE ANTIFUNGAL ACTIVITY OF BLACK, WHITE, AND GREEN TEA KOMBUCHA EXTRACTS AGAINST DERMATOPHYTE FUNGIen
dc.typeArtigopt
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas