Publicação: Treatment of Endometriosis with Local Acetylsalicylic Acid Injection: Experimental Study in Rabbits
dc.contributor.author | Siqueira, Juliana Menezes [UNESP] | |
dc.contributor.author | Barreto, Adriana Beatriz [UNESP] | |
dc.contributor.author | Saad-Hossne, Rogerio [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:32:39Z | |
dc.date.available | 2014-05-20T13:32:39Z | |
dc.date.issued | 2011-11-01 | |
dc.description.abstract | The objective of the present study was to estimate the effects of introduction of acetylsalicylic acid solution into peritoneal implants in autologous endometrium as a method for treating endometriosis. Forty adult female rabbits were subdivided into 4 groups of 10 rabbits each, and endometriosis was induced via autotransplantation of endometrial fragments into the peritoneal cavity. At 30 days after induction of endometriosis, all animals were randomly assigned to 1 of 2 protocols. In protocol 1, animals were evaluated at 24 hours after treatment; group 1 (control) received physiologic solution, and group 2 received acetylsalicylic acid. In protocol 2, animals were evaluated at 10 days after treatment, group 3 (control) and group 4 received acetylsalicylic acid. After measuring the lesion, the endometriotic focus was removed and prepared for mounting on slides for histologic analysis. Imaging software was used for analysis of the total remaining area of endometrial tissue. The affected area in acetylsalicylic acid treated animals was smaller than that in control animals at 24 hours and 10 days after treatment; a significant difference was found between control and treated groups (p < .001). Statistical analysis comparing protocols 1 and 2 demonstrated no differences between controls groups or acetylsalicylic acid groups (p = .30), and no differences between times (p = .75). Acetylsalicylic acid solution led to less growth (or higher involution) of endometrial implants. Acetylsalicylic acid injected directly into endometriotic foci was effective in their destruction. This presents new perspectives for treatment of endometriosis and for clinical applications based on further clinical studies. Journal of Minimally Invasive Gynecology (2011) 18, 800-806 (C) 2011 AAGL. All rights reserved. | en |
dc.description.affiliation | São Paulo State Univ UNESP, Botucatu Med Sch, Dept Surg, São Paulo, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ UNESP, Botucatu Med Sch, Dept Surg, São Paulo, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.format.extent | 800-806 | |
dc.identifier | http://dx.doi.org/10.1016/j.jmig.2011.08.721 | |
dc.identifier.citation | Journal of Minimally Invasive Gynecology. New York: Elsevier B.V., v. 18, n. 6, p. 800-806, 2011. | |
dc.identifier.doi | 10.1016/j.jmig.2011.08.721 | |
dc.identifier.issn | 1553-4650 | |
dc.identifier.uri | http://hdl.handle.net/11449/11143 | |
dc.identifier.wos | WOS:000296942100022 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Journal of Minimally Invasive Gynecology | |
dc.relation.ispartofjcr | 3.061 | |
dc.relation.ispartofsjr | 1,105 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Acetylsalicylic acid | en |
dc.subject | Endometriosis | en |
dc.subject | Experimental treatment | en |
dc.title | Treatment of Endometriosis with Local Acetylsalicylic Acid Injection: Experimental Study in Rabbits | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatu | pt |
unesp.department | Cirurgia e Ortopedia - FMB | pt |
Arquivos
Licença do Pacote
1 - 2 de 2
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição:
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição: