Publicação: Comparative genomic hybridization analysis detects frequent over-representation of DNA sequences at 3q, 7p, and 8q in head and neck carcinomas
dc.contributor.author | Bergamo, N. A. | |
dc.contributor.author | Rogatto, Silvia Regina [UNESP] | |
dc.contributor.author | Poli-Frederico, R. C. | |
dc.contributor.author | Reis, Patricia Pintor dos [UNESP] | |
dc.contributor.author | Kowalski, L. P. | |
dc.contributor.author | Zielenska, M. | |
dc.contributor.author | Squire, J. A. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | AC Camargo Hosp | |
dc.contributor.institution | Univ Toronto | |
dc.contributor.institution | Ontario Canc Inst | |
dc.date.accessioned | 2014-05-20T15:19:48Z | |
dc.date.available | 2014-05-20T15:19:48Z | |
dc.date.issued | 2000-05-01 | |
dc.description.abstract | Comparative genomic hybridization (CGH) was used to identify chromosomal imbalances in 19 samples of squamous cell carcinoma of the head and neck (HNSCC). The chromosome arms most often or er-represented were 3q (48%), 8q (42%), and 7p (32%); in many cases, these changes were observed at high copy number. Other commonly over-represented sites were 1q, 2q, 6p, 6q, and 18q. The most frequently under-represented segments were 3p and 22q. Loss of heterozygosity of two polymorphic microsatellite loci from chromosome 22 was observed in two tongue tumors, in agreement with the CGH analysis. Gains of 1q and 2q material were detected in patients exhibiting a clinical history of recurrence and/or metastasis followed by terminal disease. This association suggests that gain of 1q and 2q map be a new marker of head and neck tumors with a refractory clinical response. (C) 2000 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | Univ Estadual Paulista, Dept Genet, Inst Biociencias, UNESP,IB, BR-18618000 São Paulo, Brazil | |
dc.description.affiliation | AC Camargo Hosp, Dept Head & Neck Surg, São Paulo, Brazil | |
dc.description.affiliation | Univ Toronto, Hosp Sick Children, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada | |
dc.description.affiliation | Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1X8, Canada | |
dc.description.affiliation | Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1X8, Canada | |
dc.description.affiliation | Ontario Canc Inst, Toronto, ON M4X 1K9, Canada | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Genet, Inst Biociencias, UNESP,IB, BR-18618000 São Paulo, Brazil | |
dc.format.extent | 48-55 | |
dc.identifier | http://dx.doi.org/10.1016/S0165-4608(99)00213-7 | |
dc.identifier.citation | Cancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 119, n. 1, p. 48-55, 2000. | |
dc.identifier.doi | 10.1016/S0165-4608(99)00213-7 | |
dc.identifier.issn | 0165-4608 | |
dc.identifier.lattes | 2259986546265579 | |
dc.identifier.lattes | 1109525021631011 | |
dc.identifier.orcid | 0000-0003-3775-3797 | |
dc.identifier.uri | http://hdl.handle.net/11449/31182 | |
dc.identifier.wos | WOS:000087079600009 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Cancer Genetics and Cytogenetics | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Comparative genomic hybridization analysis detects frequent over-representation of DNA sequences at 3q, 7p, and 8q in head and neck carcinomas | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
unesp.author.lattes | 1109525021631011[4] | |
unesp.author.lattes | 2259986546265579 | |
unesp.author.orcid | 0000-0003-3775-3797[4] | |
unesp.author.orcid | 0000-0002-0481-156X[5] | |
unesp.author.orcid | 0000-0001-5865-9308[5] | |
unesp.author.orcid | 0000-0002-9863-468X[7] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatu | pt |
unesp.department | Urologia - FMB | pt |
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