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Comparative eye and liver differentially expressed genes reveal monochromatic vision and cancer resistance in the shortfin mako shark (Isurus oxyrinchus)

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dc.contributor.authorDomingues, Rodrigo R.
dc.contributor.authorMastrochirico-Filho, Vito Antonio [UNESP]
dc.contributor.authorMendes, Natalia J. [UNESP]
dc.contributor.authorHashimoto, Diogo T. [UNESP]
dc.contributor.authorCoelho, Rui
dc.contributor.authorda Cruz, Vanessa Paes [UNESP]
dc.contributor.authorAntunes, Agostinho
dc.contributor.authorForesti, Fausto [UNESP]
dc.contributor.authorMendonça, Fernando F.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionI.P.)
dc.contributor.institutionUniversidade do Algarve
dc.contributor.institutionUniversidade do Porto
dc.date.accessioned2020-12-12T02:21:52Z
dc.date.available2020-12-12T02:21:52Z
dc.date.issued2020-11-01
dc.description.abstractThe shortfin mako, Isurus oxyrinchus is an oceanic pelagic shark found worldwide in tropical and subtropical waters. However, the understanding of its biology at molecular level is still incipient. We sequenced the messenger RNA isolated from eye and liver tissues. De novo transcriptome yielded a total of 705,940 transcripts. A total of 3774 genes were differentially expressed (DEGs), with 1612 in the eye and 2162 in the liver. Most DEGs in the eye were related to structural and signaling functions, including nonocular and ocular opsin genes, whereas nine out of ten most overexpressed genes in the liver were related to tumor suppression, wound healing, and human diseases. Furthermore, DEGs findings provide insights on the monochromatic shark vision and a repertory of cancer-related genes, which may be insightful to elucidate shark resistance to cancer. Therefore, our results provide valuable sequence resources for future functional and population studies.en
dc.description.affiliationDepartamento de Ciências do Mar Instituto do Mar Universidade Federal de São Paulo – UNIFESP, Rua Carvalho de Mendonça, 144
dc.description.affiliationCentro de Aquicultura da UNESP Universidade Estadual Paulista – UNESP, Via de Acesso Prof. Paulo Donato Castellane, s/n
dc.description.affiliationInstituto Português do Mar e da Atmosfera (IPMA I.P.), Av. 5 Outubro
dc.description.affiliationCentro de Ciências do Mar (CCMAR) Universidade do Algarve, Campus de Gambelas
dc.description.affiliationLaboratório de Biologia e Genética de Peixes Instituto de Biociências de Botucatu Universidade Estadual Paulista – UNESP
dc.description.affiliationCIIMAR/CIMAR Centro Interdisciplinar de Investigação Marinha e Ambiental Universidade do Porto, Av. General Norton de Matos, s/n
dc.description.affiliationDepartmento de Biologia Faculdade de Ciências Universidade do Porto, Rua do Campo Alegre, s/n
dc.description.affiliationUnespCentro de Aquicultura da UNESP Universidade Estadual Paulista – UNESP, Via de Acesso Prof. Paulo Donato Castellane, s/n
dc.description.affiliationUnespLaboratório de Biologia e Genética de Peixes Instituto de Biociências de Botucatu Universidade Estadual Paulista – UNESP
dc.description.sponsorshipEuropean Regional Development Fund
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/19740-7
dc.description.sponsorshipIdFAPESP: 2017/02420-8
dc.description.sponsorshipIdFAPESP: 2018/21319-9
dc.format.extent4817-4826
dc.identifierhttp://dx.doi.org/10.1016/j.ygeno.2020.08.037
dc.identifier.citationGenomics, v. 112, n. 6, p. 4817-4826, 2020.
dc.identifier.doi10.1016/j.ygeno.2020.08.037
dc.identifier.issn1089-8646
dc.identifier.issn0888-7543
dc.identifier.scopus2-s2.0-85090326933
dc.identifier.urihttp://hdl.handle.net/11449/201013
dc.language.isoeng
dc.relation.ispartofGenomics
dc.sourceScopus
dc.subjectElasmobranch
dc.subjectGene ontology
dc.subjectPhotoreception
dc.subjectTranscriptomics
dc.subjectTumor suppression
dc.titleComparative eye and liver differentially expressed genes reveal monochromatic vision and cancer resistance in the shortfin mako shark (Isurus oxyrinchus)en
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentGenética - IBBpt

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Jaboticabal - CAUNESP - Centro de Aquicultura da Unesp
Botucatu - IBB - Instituto de Biociências