Logotipo do repositório
 

Publicação:
Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols

Resumo

The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.

Descrição

Palavras-chave

Arrabidaea brachypoda, Bignoniaceae, Gastric ulcer, Gastroprotective effect, Glycosylated dimeric flavonoids, In vivo assays

Idioma

Inglês

Como citar

Phytochemistry, v. 135, p. 93-105.

Itens relacionados

Financiadores

Unidades

Departamentos

Cursos de graduação

Programas de pós-graduação