Effects of chronic stress on nicotine-induced locomotor activity and corticosterone release in adult and adolescent rats
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Blackwell Publishing
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We examined nicotine-induced locomotion and increase in corticosterone plasma levels in adolescent and adult animals exposed to chronic restraint stress. Adolescent [postnatal day (P) 28-37] and adult (P60-67) rats were restrained for 2 hours once daily for 7 days. Three days after the last exposure to stress, the animals were challenged with saline or nicotine (0.4 mg/kg subcutaneously). Nicotine-induced locomotion was recorded in an activity cage. Trunk blood samples were collected in a subset of adolescent and adult rats and plasma corticosterone levels were determined by radioimmunoassay. Exposure to stress did not affect the nicotine-induced locomotor- or corticosterone-activating effects in both ages.
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corticosterone, cross-sensitization, locomotor activity, nicotine, rat, stress
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Inglês
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Addiction Biology. Oxford: Blackwell Publishing, v. 13, n. 1, p. 63-69, 2008.
