Publicação: Sistemas biodegradáveis contendo acetato de prednisolona para administração orbitária
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Data
2009-07-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
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Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
Purpose: The present study aimed to evaluate an injectable extended-release formulation of prednisolone acetate (PA) for orbital administration. Methods: Microspheres (MEs) of poly-ε-caprolactone (PCL) containing PA were developed by the method of solvent evaporation. The MEs obtained were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), encapsulation efficiency and in vitro release profile. The in vivo release profile was evaluated in rabbits after periocular injection of an aqueous suspension of MEs. The local biocompatibility of the system was verified by histopathologic analysis of the deployment region. Results: After MEs preparation, morphological analysis by SEM showed the feasibility of the employed method. The content of PA encapsulated was 43 ± 7% and can be considered as satisfactory. The system characterization by DSC technique, in addition to confirm the system stability, did not indicate the existence of interaction between the drug and the polymer. The in vitro release study showed the prolonged-release features of the developed system. Preliminary in vivo study showed the absence of local toxicity and confirmed the prolonged release profile of PA from MEs, suggesting the viability of the developed system for the treatment of orbital inflammatory diseases. Conclusion: The results obtained in this work are relevant and accredit the system developed as a possible alternative to the treatment of inflammatory orbitopathy.
Descrição
Palavras-chave
Absorbable implants, Delayed-action preparations, Drug carriers, Drug delivery systems, Drug implants/administration & dosage, Orbital diseases/drug therapy, Polymers, Prednisolone/administration dosage, antiinflammatory agent, biomaterial, drug carrier, drug derivative, microsphere, polycaprolactone, polyester, prednisolone, prednisolone acetate, animal, chemistry, delayed release formulation, differential scanning calorimetry, drug effect, female, materials testing, rabbit, scanning electron microscopy, vitreous body, Animals, Anti-Inflammatory Agents, Biocompatible Materials, Calorimetry, Differential Scanning, Delayed-Action Preparations, Drug Carriers, Female, Materials Testing, Microscopy, Electron, Scanning, Microspheres, Polyesters, Prednisolone, Rabbits, Vitreous Body
Idioma
Português
Como citar
Arquivos Brasileiros de Oftalmologia, v. 72, n. 4, p. 444-450, 2009.
