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Poly(Lactide-co-Glycolide) Nanocapsules Containing Benzocaine: Influence of the Composition of the Oily Nucleus on Physico-Chemical Properties and Anesthetic Activity

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dc.contributor.authorSilva de Melo, Nathalie Ferreira [UNESP]
dc.contributor.authorGrillo, Renato [UNESP]
dc.contributor.authorGuilherme, Viviane Aparecida
dc.contributor.authorde Araujo, Daniele Ribeiro
dc.contributor.authorde Paula, Eneida
dc.contributor.authorRosa, Andre Henrique [UNESP]
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2014-05-20T13:12:12Z
dc.date.available2014-05-20T13:12:12Z
dc.date.issued2011-08-01
dc.description.abstractThe aim of this work was to investigate the influence of the oily nucleus composition on physico-chemical properties and anesthetic activity of poly (lactide-co-glycolide) nanocapsules with benzocaine.Nanocapsules containing benzocaine were prepared with three different oily nucleus composition and characterized by mean diameter, polydispersivity, zeta potential, pH and stability were investigated as a function of time. In vitro release kinetics were performed in a system with two compartments separated by a cellulose membrane. Intensity and duration of analgesia were evaluated in rats by sciatic nerve blockade.The greatest stability, slower release profile and improvement in the local anesthetic activity of BZC were obtained with the formulation using USP mineral oil as component.Results from our study provide useful perspectives on selection of the primary materials needed to produce suspensions of polymeric nanocapsules able to act as carriers of BZC, with potential future application in the treatment of pain.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Environm Engn, BR-18087180 Sorocaba, SP, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Dept Biochem, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationFed Univ ABC UFABC, Human & Nat Sci Ctr, BR-09210170 Santo Andre, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Environm Engn, BR-18087180 Sorocaba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 06-00121-9
dc.description.sponsorshipIdFAPESP: 07/00127-0
dc.format.extent1984-1994
dc.identifierhttp://dx.doi.org/10.1007/s11095-011-0425-6
dc.identifier.citationPharmaceutical Research. New York: Springer/plenum Publishers, v. 28, n. 8, p. 1984-1994, 2011.
dc.identifier.doi10.1007/s11095-011-0425-6
dc.identifier.issn0724-8741
dc.identifier.lattes2188736885721242
dc.identifier.orcid0000-0002-2042-018X
dc.identifier.orcid0000-0002-0284-5782
dc.identifier.urihttp://hdl.handle.net/11449/191
dc.identifier.wosWOS:000292518800017
dc.language.isoeng
dc.publisherSpringer/plenum Publishers
dc.relation.ispartofPharmaceutical Research
dc.relation.ispartofjcr3.335
dc.relation.ispartofsjr1,077
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbenzocaineen
dc.subjectlocal anestheticen
dc.subjectnanocapsuleen
dc.subjectoily nucleusen
dc.subjectPLGAen
dc.titlePoly(Lactide-co-Glycolide) Nanocapsules Containing Benzocaine: Influence of the Composition of the Oily Nucleus on Physico-Chemical Properties and Anesthetic Activityen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer/plenum Publishers
dspace.entity.typePublication
unesp.author.lattes5228846314663888[6]
unesp.author.lattes2188736885721242[2]
unesp.author.orcid0000-0002-2042-018X[6]
unesp.author.orcid0000-0002-0284-5782[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Sorocabapt
unesp.departmentEngenharia Ambiental - ICTSpt

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Sorocaba - ICTS - Instituto de Ciência e Tecnologia