Publicação: Analysis of the TAX1BP1 gene in head and neck cancer patients
dc.contributor.author | Ruiz, Mariangela Torreglosa | |
dc.contributor.author | Balachi, Janayna Fernanda [UNESP] | |
dc.contributor.author | Fernandes, Raquel Aldrighi | |
dc.contributor.author | Silva Galbiatti, Ana Livia | |
dc.contributor.author | Maniglia, Jose Victor | |
dc.contributor.author | Pavarino-Bertelli, Erika Cristina | |
dc.contributor.author | Goloni-Bertollo, Eny Maria | |
dc.contributor.institution | Faculdade de Medicina de São José do Rio Preto (FAMERP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | UNORP São José do Rio Preto | |
dc.contributor.institution | UPGEM | |
dc.date.accessioned | 2014-05-20T15:33:30Z | |
dc.date.available | 2014-05-20T15:33:30Z | |
dc.date.issued | 2010-03-01 | |
dc.description.abstract | In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T. A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism. | en |
dc.description.affiliation | FAMERP, Med Sch Sao Jose do Rio Preto, Genet & Mol Biol Unit, Sao Jose do Rio Preto, Brazil | |
dc.description.affiliation | UNESP Sao Jose do Rio Preto, Sao Jose do Rio Preto, Brazil | |
dc.description.affiliation | UNORP Sao Jose do Rio Preto, Sao Jose do Rio Preto, Brazil | |
dc.description.affiliation | FAMERP, Med Sch Sao Jose do Rio Preto, Dept Mol Biol, Sao Jose do Rio Preto, Brazil | |
dc.description.affiliation | UPGEM, Unidade Pesquisa Genet & Biol Mol, BR-15090000 Sao Jose do Rio Preto, Brazil | |
dc.description.affiliation | FAPESP, São Paulo, Brazil | |
dc.description.affiliation | Ctr Nacl Desenvolvimento Cient & Tecnol CNPq, São Paulo, Brazil | |
dc.description.affiliationUnesp | UNESP Sao Jose do Rio Preto, Sao Jose do Rio Preto, Brazil | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.format.extent | 193-198 | |
dc.identifier | http://dx.doi.org/10.1590/S1808-86942010000200008 | |
dc.identifier.citation | Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 76, n. 2, p. 193-198, 2010. | |
dc.identifier.file | S1808-86942010000200008.pdf | |
dc.identifier.issn | 1808-8694 | |
dc.identifier.scielo | S1808-86942010000200008 | |
dc.identifier.uri | http://hdl.handle.net/11449/42106 | |
dc.identifier.wos | WOS:000293572100008 | |
dc.language.iso | eng | |
dc.publisher | Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial | |
dc.relation.ispartof | Brazilian Journal of Otorhinolaryngology | |
dc.relation.ispartofjcr | 1.412 | |
dc.relation.ispartofsjr | 0,443 | |
dc.rights.accessRights | Acesso aberto | pt |
dc.source | Web of Science | |
dc.subject | Alcohol drinking | en |
dc.subject | Genetics | en |
dc.subject | Head and neck neoplasms | en |
dc.subject | Tobacco | en |
dc.title | Analysis of the TAX1BP1 gene in head and neck cancer patients | en |
dc.type | Artigo | pt |
dcterms.license | http://www.scielo.br/revistas/bjorl/paboutj.htm | |
dcterms.rightsHolder | Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial | |
dspace.entity.type | Publication | |
unesp.author.orcid | 0000-0002-9765-2659[5] | |
unesp.author.orcid | 0000-0002-2622-4673[7] | |
unesp.author.orcid | 0000-0003-0959-0695[6] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Preto | pt |
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