Controlling proteolysis of Clp peptidase: a possible target for combating mitochondrial diseases
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Undergraduate course
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Acesso aberto
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Abstract
Some mechanisms of cellular stress, aging, and apoptosis are related to proteolysis. With respect to ClpP, little is known about the mechanical manner in which the substrate is hydrolyzed in and released from the degradation chamber. Furthermore, what would be the real influence of ClpP in mammalian UPR mt ?
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Keywords
Cellular function, Chaperone, Protease, Proteostasis
Language
English
Citation
International Journal of Biochemistry and Cell Biology, v. 110, p. 140-142.
