Logo do repositório
 

Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro

Página do item simplificado
dc.contributor.authorSaivish, Marielena Vogel
dc.contributor.authorPacca, Carolina Colombelli [UNESP]
dc.contributor.authorda Costa, Vivaldo Gomes [UNESP]
dc.contributor.authorde Lima Menezes, Gabriela
dc.contributor.authorda Silva, Roosevelt Alves
dc.contributor.authorNebo, Liliane
dc.contributor.authorda Silva, Gislaine Celestino Dutra
dc.contributor.authorde Aguiar Milhim, Bruno Henrique Gonçalves
dc.contributor.authorda Silva Teixeira, Igor
dc.contributor.authorHenrique, Tiago
dc.contributor.authorMistrão, Natalia Franco Bueno
dc.contributor.authorHernandes, Victor Miranda
dc.contributor.authorZini, Nathalia
dc.contributor.authorde Carvalho, Ana Carolina
dc.contributor.authorFontoura, Marina Alves
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorSacchetto, Lívia
dc.contributor.authorMarques, Rafael Elias
dc.contributor.authorNogueira, Maurício Lacerda
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto
dc.contributor.institutionCentro Nacional de Pesquisa em Energia e Materiais (CNPEM)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFaceres Medical School
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte
dc.contributor.institutionUniversidade Federal de Jataí
dc.contributor.institutionThe University of Texas Medical Branch
dc.date.accessioned2023-07-29T13:44:24Z
dc.date.available2023-07-29T13:44:24Z
dc.date.issued2023-02-01
dc.description.abstractIlhéus virus (ILHV) is a neglected mosquito-borne flavivirus. ILHV infection may lead to Ilhéus fever, an emerging febrile disease like dengue fever with the potential to evolve into a severe neurological disease characterized by meningoencephalitis; no specific treatments are available for this disease. This study assessed the antiviral properties of caffeic acid, an abundant component of plant-based food products that is also compatible with the socioeconomic limitations associated with this neglected infectious disease. The in vitro activity of caffeic acid on ILHV replication was investigated in Vero and A549 cell lines using plaque assays, quantitative RT-PCR, and immunofluorescence assays. We observed that 500 µM caffeic acid was virucidal against ILHV. Molecular docking indicated that caffeic acid might interact with an allosteric binding site on the envelope protein.en
dc.description.affiliationLaboratório de Pesquisas em Virologia Departamento de Doenças Dermatológicas Infecciosas e Parasitárias Faculdade de Medicina de São José do Rio Preto, SP
dc.description.affiliationBrazilian Biosciences National Laboratory Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), SP
dc.description.affiliationLaboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, SP
dc.description.affiliationFaceres Medical School, SP
dc.description.affiliationDepartamento de Biofísica e Farmacologia Universidade Federal do Rio Grande do Norte, RN
dc.description.affiliationUnidade Especial de Ciências Exatas Universidade Federal de Jataí, GO
dc.description.affiliationLaboratório de Marcadores Moleculares e Bioinformática Departamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto, SP
dc.description.affiliationDepartment of Pathology The University of Texas Medical Branch
dc.description.affiliationUnespLaboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, SP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCenter for Information Technology
dc.description.sponsorshipCenter for Scientific Review
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipOffice of Extramural Research, National Institutes of Health
dc.description.sponsorshipOffice of Research Infrastructure Programs, National Institutes of Health
dc.description.sponsorshipIdFAPESP: 2013/21719-3
dc.description.sponsorshipIdCenter for Information Technology: U01AI151807
dc.description.sponsorshipIdCenter for Scientific Review: U01AI151807
dc.description.sponsorshipIdNational Institutes of Health: U01AI151807
dc.description.sponsorshipIdOffice of Extramural Research, National Institutes of Health: U01AI151807
dc.description.sponsorshipIdOffice of Research Infrastructure Programs, National Institutes of Health: U01AI151807
dc.identifierhttp://dx.doi.org/10.3390/v15020494
dc.identifier.citationViruses, v. 15, n. 2, 2023.
dc.identifier.doi10.3390/v15020494
dc.identifier.issn1999-4915
dc.identifier.scopus2-s2.0-85149254337
dc.identifier.urihttp://hdl.handle.net/11449/248450
dc.language.isoeng
dc.relation.ispartofViruses
dc.sourceScopus
dc.subjectantiviral activity
dc.subjectcaffeic acid
dc.subjectIlhéus virus
dc.subjectin silico analysis
dc.subjectinhibition
dc.titleCaffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitroen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-7627-621X[1]
unesp.author.orcid0000-0002-9359-0198[3]
unesp.author.orcid0000-0002-8944-8148[4]
unesp.author.orcid0000-0001-5624-4790[5]
unesp.author.orcid0000-0001-5672-2609[8]
unesp.author.orcid0000-0001-7424-4014[9]
unesp.author.orcid0000-0001-7996-6497[14]
unesp.author.orcid0000-0002-1192-7210[15]
unesp.author.orcid0000-0001-9716-6899[17]
unesp.author.orcid0000-0002-6949-0947[18]
unesp.author.orcid0000-0003-1102-2419[19]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

Arquivos

Coleções

São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas