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Effects of Helicobacter pylori Infection on the Expressions of Bax and Bcl-2 in Patients with Chronic Gastritis and Gastric Cancer

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dc.contributor.authorBartchewsky, Waldemar
dc.contributor.authorMartini, Mariana R.
dc.contributor.authorSquassoni, Aline C.
dc.contributor.authorAlvarez, Marisa C.
dc.contributor.authorLadeira, Marcelo S. P. [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorTrevisan, Miriam A.
dc.contributor.authorPedrazzoli, Jose
dc.contributor.authorRibeiro, Marcelo L.
dc.contributor.institutionUniv Sao Francisco
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLab MULTIPAT
dc.date.accessioned2014-05-20T13:33:21Z
dc.date.available2014-05-20T13:33:21Z
dc.date.issued2010-01-01
dc.description.abstractThe aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected; 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by PCR, and the expression values were determined by quantitative real-time PCR and immunohistochemistry. Our data showed that the up-regulationary effects of H. pylori infection on the proapoptotic gene, Bax, were stronger than its induction of Bcl-2; this effect may increase apoptosis in patients with chronic gastritis. In patients with gastric cancer, the up-regulation of the anti-apoptotic gene, Bcl-2, counteracted the pro-apoptotic effects of Bax, leading to a deregulation of apoptosis-associated gene expression, favoring cell proliferation. Thus, the disturbance in Bax and Bcl-2 balance, induced by H. pylori, might be important in gastric cancer development.en
dc.description.affiliationUniv Sao Francisco, Unidade Integrada Farmacol & Gastroenterol, BR-12900000 Braganca Paulista, SP, Brazil
dc.description.affiliationUNESP, Dpto Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dpto Patol, Botucatu, SP, Brazil
dc.description.affiliationLab MULTIPAT, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Dpto Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dpto Patol, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 05/56736-9
dc.description.sponsorshipIdFAPESP: 06/29925-0
dc.format.extent111-116
dc.identifierhttp://dx.doi.org/10.1007/s10620-008-0699-7
dc.identifier.citationDigestive Diseases and Sciences. Dordrecht: Springer, v. 55, n. 1, p. 111-116, 2010.
dc.identifier.doi10.1007/s10620-008-0699-7
dc.identifier.issn0163-2116
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/11410
dc.identifier.wosWOS:000273520500018
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofDigestive Diseases and Sciences
dc.relation.ispartofjcr2.819
dc.relation.ispartofsjr1,330
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHelicobacter pylorien
dc.subjectGastric canceren
dc.subjectBaxen
dc.subjectBcl-2en
dc.subjectReal-time PCRen
dc.titleEffects of Helicobacter pylori Infection on the Expressions of Bax and Bcl-2 in Patients with Chronic Gastritis and Gastric Canceren
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0003-4529-7832[9]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt
unesp.departmentPatologia - FMBpt

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Botucatu - FMB - Faculdade de Medicina