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Histological assessment of ovaries and uterus of rats subjected to nandrolone decanoate treatment

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dc.contributor.authorGerez, JR
dc.contributor.authorFrei, Fernando [UNESP]
dc.contributor.authorCamargo, ICC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:22:03Z
dc.date.available2014-05-20T13:22:03Z
dc.date.issued2005-07-01
dc.description.abstractThis study aimed to analyze the effects of nandrolone decanoate on the ovaries and uterus of adult females rats. This drug was administered intraperitoneally, at one, two and three doses of 3 mg nandrolone decanoate/kg of body weight, respectively, in the first, second and third week of treatment. The females of the control group received a physiological solution. The rats treated with nandrolone decanoate showed estral acyclicity and there was destruction of follicular units and an absence of corpus luteum in the ovaries. In the uterus, the drug promoted morphological alterations, characterized by vacuolated epithelium and endometrial stroma fibrosis. Ovary, uterus and pituitary weights were not affected by the steroid treatment. Nandrolone decanoate affects the sexual cycle and promotes histological alterations in the ovaries and uterus of adult female rats. (C) 2005 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Fac Sci & Letters, Dept Biol Sci, BR-19806900 Assis, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Sci & Letters, Dept Biol Sci, BR-19806900 Assis, SP, Brazil
dc.format.extent77-80
dc.identifierhttp://dx.doi.org/10.1016/j.contraception.2005.02.001
dc.identifier.citationContraception. New York: Elsevier B.V., v. 72, n. 1, p. 77-80, 2005.
dc.identifier.doi10.1016/j.contraception.2005.02.001
dc.identifier.issn0010-7824
dc.identifier.lattes4165274708509804
dc.identifier.urihttp://hdl.handle.net/11449/6430
dc.identifier.wosWOS:000230425200014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofContraception
dc.relation.ispartofjcr2.894
dc.relation.ispartofsjr1,921
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectnandrolone decanoatept
dc.subjectovariespt
dc.subjectuteruspt
dc.subjecthistologypt
dc.subjectadult female ratspt
dc.titleHistological assessment of ovaries and uterus of rats subjected to nandrolone decanoate treatmenten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes4165274708509804
unesp.author.orcid0000-0002-3354-8430[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências e Letras, Assispt
unesp.departmentCiências Biológicas - FCLASpt

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