Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats
dc.contributor.author | Nassar, P. O. [UNESP] | |
dc.contributor.author | Nassar, C. A. | |
dc.contributor.author | Guimaraes, M. R. [UNESP] | |
dc.contributor.author | Aquino, S. G. [UNESP] | |
dc.contributor.author | Andia, D. C. [UNESP] | |
dc.contributor.author | Muscara, M. N. | |
dc.contributor.author | Spolidório, Denise Madalena Palomari [UNESP] | |
dc.contributor.author | Rossa, C. [UNESP] | |
dc.contributor.author | Spolidório, Luis Carlos [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Estadual do Oeste do Paraná (UNIOESTE) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2013-09-30T18:32:32Z | |
dc.date.accessioned | 2014-05-20T13:45:16Z | |
dc.date.available | 2013-09-30T18:32:32Z | |
dc.date.available | 2014-05-20T13:45:16Z | |
dc.date.issued | 2009-08-01 | |
dc.description.abstract | Background and Objective:Cyclosporine A treatment is important in the therapy of a number of medical conditions; however, alveolar bone loss is an important negative side-effect of this drug. As such, we evaluated whether concomitant administration of simvastatin would minimize cyclosporine A-associated alveolar bone loss in rats subjected, or not, to experimental periodontal disease.Material and Methods:Groups of 10 rats each were treated with cyclosporine A (10 mg/kg/day), simvastatin (20 mg/kg/day), cyclosporine A and simvastatin concurrently (cyclosporine A/simvastatin) or vehicle for 30 days. Four other groups of 10 rats each received a cotton ligature around the lower first molar and were treated similarly with cyclosporine A, simvastatin, cyclosporine A/simvastatin or vehicle. Calcium (Ca(2+)), phosphorus and alkaline phosphatase levels were evaluated in serum. Expression levels of interleukin-1 beta, prostaglandin E(2) and inducible nitric oxide synthase were evaluated in the gingivomucosal tissues. Bone volume and numbers of osteoblasts and osteoclasts were also analyzed.Results:Treatment with cyclosporine A in rats, with or without ligature, was associated with bone loss, represented by a lower bone volume and an increase in the number of osteoclasts. Treatment with cyclosporine A was associated with bone resorption, whereas simvastatin treatment improved cyclosporine A-associated alveolar bone loss in all parameters studied. In addition, simvastatin, in the presence of inflammation, can act as an anti-inflammatory agent.Conclusion:This study shows that simvastatin therapy leads to a reversal of the cyclosporine A-induced bone loss, which may be mediated by downregulation of interleukin-1 beta and prostaglandin E(2) production. | en |
dc.description.affiliation | State Univ São Paulo, Dent Sch Araraquara, Dept Periodontol, Araraquara, SP, Brazil | |
dc.description.affiliation | Univ State W Parana Unioeste, Cascavel Dent Sch, Dept Periodontol, Cascavel, Parana, Brazil | |
dc.description.affiliation | State Univ São Paulo UNESP, Dent Sch Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil | |
dc.description.affiliation | Univ São Paulo USP, Inst Biomed Sci, Dept Pharmacol, São Paulo, Brazil | |
dc.description.affiliationUnesp | State Univ São Paulo, Dent Sch Araraquara, Dept Periodontol, Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | State Univ São Paulo UNESP, Dent Sch Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: 04/09851-4. | |
dc.format.extent | 479-488 | |
dc.identifier | http://dx.doi.org/10.1111/j.1600-0765.2008.01143.x | |
dc.identifier.citation | Journal of Periodontal Research. Malden: Wiley-blackwell Publishing, Inc, v. 44, n. 4, p. 479-488, 2009. | |
dc.identifier.doi | 10.1111/j.1600-0765.2008.01143.x | |
dc.identifier.issn | 0022-3484 | |
dc.identifier.lattes | 2640929291808415 | |
dc.identifier.uri | http://hdl.handle.net/11449/15913 | |
dc.identifier.wos | WOS:000267426900008 | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing, Inc | |
dc.relation.ispartof | Journal of Periodontal Research | |
dc.relation.ispartofjcr | 2.878 | |
dc.relation.ispartofsjr | 0,927 | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Web of Science | |
dc.subject | simvastatin | en |
dc.subject | cyclosporine A | en |
dc.subject | alveolar bone loss | en |
dc.subject | periodontitis | en |
dc.title | Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats | en |
dc.type | Artigo | pt |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dcterms.rightsHolder | Wiley-blackwell Publishing, Inc | |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | b3ba3d9c-022e-4521-8805-0bcceea7372e | |
relation.isDepartmentOfPublication.latestForDiscovery | b3ba3d9c-022e-4521-8805-0bcceea7372e | |
relation.isOrgUnitOfPublication | ca4c0298-cd82-48ee-a9c8-c97704bac2b0 | |
relation.isOrgUnitOfPublication.latestForDiscovery | ca4c0298-cd82-48ee-a9c8-c97704bac2b0 | |
unesp.author.lattes | 2640929291808415 | |
unesp.author.lattes | 7634063102292261[8] | |
unesp.author.orcid | 0000-0003-2376-1024[7] | |
unesp.author.orcid | 0000-0003-1705-5481[8] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara | pt |
unesp.department | Diagnóstico e Cirurgia - FOAR | pt |
unesp.department | Fisiologia e Patologia - FOAR | pt |
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