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Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats

dc.contributor.authorNassar, P. O. [UNESP]
dc.contributor.authorNassar, C. A.
dc.contributor.authorGuimaraes, M. R. [UNESP]
dc.contributor.authorAquino, S. G. [UNESP]
dc.contributor.authorAndia, D. C. [UNESP]
dc.contributor.authorMuscara, M. N.
dc.contributor.authorSpolidório, Denise Madalena Palomari [UNESP]
dc.contributor.authorRossa, C. [UNESP]
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual do Oeste do Paraná (UNIOESTE)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2013-09-30T18:32:32Z
dc.date.accessioned2014-05-20T13:45:16Z
dc.date.available2013-09-30T18:32:32Z
dc.date.available2014-05-20T13:45:16Z
dc.date.issued2009-08-01
dc.description.abstractBackground and Objective:Cyclosporine A treatment is important in the therapy of a number of medical conditions; however, alveolar bone loss is an important negative side-effect of this drug. As such, we evaluated whether concomitant administration of simvastatin would minimize cyclosporine A-associated alveolar bone loss in rats subjected, or not, to experimental periodontal disease.Material and Methods:Groups of 10 rats each were treated with cyclosporine A (10 mg/kg/day), simvastatin (20 mg/kg/day), cyclosporine A and simvastatin concurrently (cyclosporine A/simvastatin) or vehicle for 30 days. Four other groups of 10 rats each received a cotton ligature around the lower first molar and were treated similarly with cyclosporine A, simvastatin, cyclosporine A/simvastatin or vehicle. Calcium (Ca(2+)), phosphorus and alkaline phosphatase levels were evaluated in serum. Expression levels of interleukin-1 beta, prostaglandin E(2) and inducible nitric oxide synthase were evaluated in the gingivomucosal tissues. Bone volume and numbers of osteoblasts and osteoclasts were also analyzed.Results:Treatment with cyclosporine A in rats, with or without ligature, was associated with bone loss, represented by a lower bone volume and an increase in the number of osteoclasts. Treatment with cyclosporine A was associated with bone resorption, whereas simvastatin treatment improved cyclosporine A-associated alveolar bone loss in all parameters studied. In addition, simvastatin, in the presence of inflammation, can act as an anti-inflammatory agent.Conclusion:This study shows that simvastatin therapy leads to a reversal of the cyclosporine A-induced bone loss, which may be mediated by downregulation of interleukin-1 beta and prostaglandin E(2) production.en
dc.description.affiliationState Univ São Paulo, Dent Sch Araraquara, Dept Periodontol, Araraquara, SP, Brazil
dc.description.affiliationUniv State W Parana Unioeste, Cascavel Dent Sch, Dept Periodontol, Cascavel, Parana, Brazil
dc.description.affiliationState Univ São Paulo UNESP, Dent Sch Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo USP, Inst Biomed Sci, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Dent Sch Araraquara, Dept Periodontol, Araraquara, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo UNESP, Dent Sch Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/09851-4.
dc.format.extent479-488
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0765.2008.01143.x
dc.identifier.citationJournal of Periodontal Research. Malden: Wiley-blackwell Publishing, Inc, v. 44, n. 4, p. 479-488, 2009.
dc.identifier.doi10.1111/j.1600-0765.2008.01143.x
dc.identifier.issn0022-3484
dc.identifier.lattes2640929291808415
dc.identifier.urihttp://hdl.handle.net/11449/15913
dc.identifier.wosWOS:000267426900008
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofJournal of Periodontal Research
dc.relation.ispartofjcr2.878
dc.relation.ispartofsjr0,927
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectsimvastatinen
dc.subjectcyclosporine Aen
dc.subjectalveolar bone lossen
dc.subjectperiodontitisen
dc.titleSimvastatin therapy in cyclosporine A-induced alveolar bone loss in ratsen
dc.typeArtigopt
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
dspace.entity.typePublication
relation.isDepartmentOfPublicationb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isDepartmentOfPublication.latestForDiscoveryb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.author.lattes2640929291808415
unesp.author.lattes7634063102292261[8]
unesp.author.orcid0000-0003-2376-1024[7]
unesp.author.orcid0000-0003-1705-5481[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentDiagnóstico e Cirurgia - FOARpt
unesp.departmentFisiologia e Patologia - FOARpt

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