Osseous regeneration in the presence of fibrin adhesive material (Tissucol) and epsilon-aminocaproic acid (EACA).
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Abstract
The effects of Tissucol and Tissucol/EACA on bone healing were evaluated histologically. Experimental defects were made in both tibias of 25 rats. Test materials were placed in defects in right tibias and left tibias served as control. Five animals in each group were killed at 1, 3, 7, 14 and 21 days after surgery. Results showed that: a) Tissucol did not interfere with connective and osseous tissue formation; b) Tissucol allowed new bone formation; c) Tissue residues in Tissucol groups in sections of 21-day specimens did not impair healing; d) Tissucol/EACA was usually completely resorbed and healing was complete 21 days after surgery in the Tissucol/EACA group.
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aminocaproic acid , fibrin glue , hemostatic agent , animal , bone regeneration , comparative study , drug effect , lavage , male , prostheses and orthoses , rat , tibia , tooth development , Wistar rat , wound healing , 6-Aminocaproic Acid , Animals , Bone Regeneration , Fibrin Tissue Adhesive , Hemostatics , Irrigation , Male , Odontogenesis , Prostheses and Implants , Rats , Rats, Wistar , Tibia , Wound Healing
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English
Citation
Brazilian dental journal, v. 6, n. 2, p. 77-83, 1995.
