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Effects of meperidine or saline on thermal, mechanical and electrical nociceptive thresholds in cats

dc.contributor.authorMillette, Valerie M.
dc.contributor.authorSteagall, Paulo V. M. [UNESP]
dc.contributor.authorDuke-Novakovski, Tanya
dc.contributor.authorLivingston, Alex J.
dc.contributor.institutionUniv Saskatchewan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:39:14Z
dc.date.available2014-05-20T13:39:14Z
dc.date.issued2008-11-01
dc.description.abstractObjective To measure cutaneous electrical nociceptive thresholds in relation to known thermal and mechanical stimulation for nociceptive threshold detection in cats.Study design Prospective, blinded, randomized cross-over study with 1-week washout interval.Animals Eight adult cats [bodyweight 5.1 +/- 1.8 kg (mean + SD)].Methods Mechanical nociceptive thresholds were tested using a step-wise manual inflation of a modified blood pressure bladder attached to the cat's thoracic limb. Thermal nociceptive thresholds were measured by increasing the temperature of a probe placed on the thorax. The electrical nociceptive threshold was tested using an escalating current from a constant current generator passed between electrodes placed on the thoracic region. A positive response (threshold) was recorded when cats displayed any or all of the following behaviors: leg shake, head turn, avoidance, or vocalization. Four baseline readings were performed before intramuscular injection of meperidine (5 mg kg(-1)) or an equal volume of saline. Threshold recordings with each modality were made at 15, 30, 45, 60, 90, and 120 minutes post-injection. Data were analyzed using ANOVA and paired t-tests (significance at p < 0.05).Results There were no significant changes in thermal, mechanical, or electrical thresholds after saline. Thermal thresholds increased at 15-60 minutes (p < 0.01) and mechanical threshold increased at 30 and 45 minutes after meperidine (p < 0.05). Maximum thermal threshold was +4.1 +/- 0.3 degrees C above baseline at 15 minutes while maximum mechanical threshold was 296 +/- 265 mmHg above baseline at 30 minutes after meperidine. Electrical thresholds following meperidine were not significantly different than baseline (p > 0.05). Thermal and electrical thresholds after meperidine were significantly higher than saline at 30 and 45 minutes (p < 0.05), and at 120 minutes (p < 0.05), respectively. Mechanical thresholds were significantly higher than saline treatment at 30 minutes (p <= 0.05).Conclusion and clinical relevance Electrical stimulation did not detect meperidine analgesia whereas both thermal and mechanical thresholds changed after meperidine administration in cats.en
dc.description.affiliationUniv Saskatchewan, Western Coll Vet Med, Dept Small Anim Clin Sci, Saskatoon, SK S7N 0W0, Canada
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, Botucatu, SP, Brazil
dc.format.extent543-547
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2008.00419.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia. Malden: Wiley-blackwell, v. 35, n. 6, p. 543-547, 2008.
dc.identifier.doi10.1111/j.1467-2995.2008.00419.x
dc.identifier.issn1467-2987
dc.identifier.urihttp://hdl.handle.net/11449/13606
dc.identifier.wosWOS:000260141000012
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectanalgesiaen
dc.subjectcaten
dc.subjectelectricalen
dc.subjectmechanicalen
dc.subjectthermalen
dc.subjectthresholdsen
dc.titleEffects of meperidine or saline on thermal, mechanical and electrical nociceptive thresholds in catsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentCirurgia e Anestesiologia Veterinária - FMVZpt

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