Publicação: Effects of meperidine or saline on thermal, mechanical and electrical nociceptive thresholds in cats
dc.contributor.author | Millette, Valerie M. | |
dc.contributor.author | Steagall, Paulo V. M. [UNESP] | |
dc.contributor.author | Duke-Novakovski, Tanya | |
dc.contributor.author | Livingston, Alex J. | |
dc.contributor.institution | Univ Saskatchewan | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:39:14Z | |
dc.date.available | 2014-05-20T13:39:14Z | |
dc.date.issued | 2008-11-01 | |
dc.description.abstract | Objective To measure cutaneous electrical nociceptive thresholds in relation to known thermal and mechanical stimulation for nociceptive threshold detection in cats.Study design Prospective, blinded, randomized cross-over study with 1-week washout interval.Animals Eight adult cats [bodyweight 5.1 +/- 1.8 kg (mean + SD)].Methods Mechanical nociceptive thresholds were tested using a step-wise manual inflation of a modified blood pressure bladder attached to the cat's thoracic limb. Thermal nociceptive thresholds were measured by increasing the temperature of a probe placed on the thorax. The electrical nociceptive threshold was tested using an escalating current from a constant current generator passed between electrodes placed on the thoracic region. A positive response (threshold) was recorded when cats displayed any or all of the following behaviors: leg shake, head turn, avoidance, or vocalization. Four baseline readings were performed before intramuscular injection of meperidine (5 mg kg(-1)) or an equal volume of saline. Threshold recordings with each modality were made at 15, 30, 45, 60, 90, and 120 minutes post-injection. Data were analyzed using ANOVA and paired t-tests (significance at p < 0.05).Results There were no significant changes in thermal, mechanical, or electrical thresholds after saline. Thermal thresholds increased at 15-60 minutes (p < 0.01) and mechanical threshold increased at 30 and 45 minutes after meperidine (p < 0.05). Maximum thermal threshold was +4.1 +/- 0.3 degrees C above baseline at 15 minutes while maximum mechanical threshold was 296 +/- 265 mmHg above baseline at 30 minutes after meperidine. Electrical thresholds following meperidine were not significantly different than baseline (p > 0.05). Thermal and electrical thresholds after meperidine were significantly higher than saline at 30 and 45 minutes (p < 0.05), and at 120 minutes (p < 0.05), respectively. Mechanical thresholds were significantly higher than saline treatment at 30 minutes (p <= 0.05).Conclusion and clinical relevance Electrical stimulation did not detect meperidine analgesia whereas both thermal and mechanical thresholds changed after meperidine administration in cats. | en |
dc.description.affiliation | Univ Saskatchewan, Western Coll Vet Med, Dept Small Anim Clin Sci, Saskatoon, SK S7N 0W0, Canada | |
dc.description.affiliation | Univ Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, Botucatu, SP, Brazil | |
dc.format.extent | 543-547 | |
dc.identifier | http://dx.doi.org/10.1111/j.1467-2995.2008.00419.x | |
dc.identifier.citation | Veterinary Anaesthesia and Analgesia. Malden: Wiley-blackwell, v. 35, n. 6, p. 543-547, 2008. | |
dc.identifier.doi | 10.1111/j.1467-2995.2008.00419.x | |
dc.identifier.issn | 1467-2987 | |
dc.identifier.uri | http://hdl.handle.net/11449/13606 | |
dc.identifier.wos | WOS:000260141000012 | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell | |
dc.relation.ispartof | Veterinary Anaesthesia and Analgesia | |
dc.relation.ispartofjcr | 2.064 | |
dc.relation.ispartofsjr | 0,800 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | analgesia | en |
dc.subject | cat | en |
dc.subject | electrical | en |
dc.subject | mechanical | en |
dc.subject | thermal | en |
dc.subject | thresholds | en |
dc.title | Effects of meperidine or saline on thermal, mechanical and electrical nociceptive thresholds in cats | en |
dc.type | Artigo | |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dcterms.rightsHolder | Wiley-blackwell | |
dspace.entity.type | Publication | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatu | pt |
unesp.department | Cirurgia e Anestesiologia Veterinária - FMVZ | pt |
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