Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome
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Elsevier B.V.
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Elsevier
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Background: The aim of this study was to investigate enzymatic and non-enzymatic antioxidant systems and levels of biomarker levels of oxidative damage in the saliva of patients with Down's syndrome (DS).Methods: Saliva samples were collected from 30 patients with DS and control group (age: 1424 years). Subsequently, the concentrations of superoxide dismutase, concentration of malondialdehyde, carbonylated proteins, uric acid, vitamin C and total protein, peroxidase activity and total antioxidant capacity were analyzed.Results: Patients with DS presented significantly higher concentrations of superoxide dismutase, higher levels of malondialdehyde and salivary total protein content than controls (p < 0.05). Conversely, no difference in carbonylated proteins or antioxidants (uric acid, vitamin C, peroxidase, and total antioxidant capacity) was observed between DS patients and controls (p > 0.05).Conclusion: Patients with DS are more vulnerable to oxidative stress in saliva as indicated by the significant increase in malondialdehyde and superoxide dismutase concentrations found in this study.
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Archives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 60, n. 4, p. 600-605, 2015.
