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LPS Induces Greater Bone and PDL Loss in SPARC-null Mice

dc.contributor.authorTrombetta-eSilva, J.
dc.contributor.authorYu, H.
dc.contributor.authorArias, D. N.
dc.contributor.authorRossa, C. [UNESP]
dc.contributor.authorKirkwood, K. L.
dc.contributor.authorBradshaw, A. D.
dc.contributor.institutionMed Univ S Carolina
dc.contributor.institutionErskine Coll
dc.contributor.institutionRalph H Johnson Dept Vet Affairs Med Ctr
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:31:54Z
dc.date.accessioned2014-05-20T13:45:27Z
dc.date.available2013-09-30T18:31:54Z
dc.date.available2014-05-20T13:45:27Z
dc.date.issued2011-04-01
dc.description.abstractIndividuals with periodontal disease have increased risk of tooth loss, particularly in cases with associated loss of alveolar bone and periodontal ligament (PDL). Current treatments do not predictably regenerate damaged PDL. Collagen I is the primary component of bone and PDL extracellular matrix. SPARC/Osteonectin (SP/ON) is implicated in the regulation of collagen content in healthy PDL. In this study, periodontal disease was induced by injections of lipopolysaccharide (LPS) from Aggregatibacter actinomycetemcomitans in wild-type (WT) and SP/ON-null C57/B16 mice. A 20-mu g quantity of LPS was injected between the first and second molars 3 times a week for 4 weeks, whereas PBS control was injected into the contralateral maxilla. LPS injection resulted in a significant decrease in bone volume fraction in both genotypes; however, significantly greater bone loss was detected in SP/ON-null maxilla. SP/ON-null PDL exhibited more extensive degradation of connective tissue in the gingival tissues. Although total cell numbers in the PDL of SP/ON-null were not different from those in WT, the inflammatory infiltrate was reduced in SP/ON-null PDL. Histology of collagen fibers revealed marked reductions in collagen volume fraction and in thick collagen volume fraction in the PDL of SP/ON-null mice. SP/ON protects collagen content in PDL and in alveolar bone in experimental periodontal disease.en
dc.description.affiliationMed Univ S Carolina, Ctr Oral Hlth Res, Charleston, SC 29425 USA
dc.description.affiliationMed Univ S Carolina, Gazes Cardiac Res Inst, Dept Craniofacial Biol, Charleston, SC 29425 USA
dc.description.affiliationMed Univ S Carolina, Dept Med, Div Cardiol, Charleston, SC 29425 USA
dc.description.affiliationErskine Coll, Due West, SC USA
dc.description.affiliationRalph H Johnson Dept Vet Affairs Med Ctr, Charleston, SC USA
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Diag & Surg, Fac Odontol Araraquara, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Diag & Surg, Fac Odontol Araraquara, Araraquara, SP, Brazil
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipVeteran's Administration
dc.description.sponsorshipIdNIH: T32-DE017551
dc.description.sponsorshipIdNIH: R25-HL092611
dc.description.sponsorshipIdNIH: 2P20RR017696
dc.description.sponsorshipIdNIH: HL094517
dc.description.sponsorshipIdNIH: R01-DE018290
dc.format.extent477-482
dc.identifierhttp://dx.doi.org/10.1177/0022034510391800
dc.identifier.citationJournal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 90, n. 4, p. 477-482, 2011.
dc.identifier.doi10.1177/0022034510391800
dc.identifier.issn0022-0345
dc.identifier.urihttp://hdl.handle.net/11449/15988
dc.identifier.wosWOS:000288798600013
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Dental Research
dc.relation.ispartofjcr5.380
dc.relation.ispartofsjr2,302
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSPARCen
dc.subjectperiodontal ligamenten
dc.subjectcollagenen
dc.subjectBM-40en
dc.subjectosteonectinen
dc.subjectextracellular matrixen
dc.subjectmatricellularen
dc.subjectperiodontal diseasesen
dc.subjectalveolar bone resorptionen
dc.titleLPS Induces Greater Bone and PDL Loss in SPARC-null Miceen
dc.typeArtigo
dcterms.licensehttps://mc.manuscriptcentral.com/societyimages/wes/WES_ExclusiveLicense.pdf
dcterms.rightsHolderSage Publications Inc
dspace.entity.typePublication
unesp.author.lattes7634063102292261[4]
unesp.author.orcid0000-0003-1705-5481[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentDiagnóstico e Cirurgia - FOARpt

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