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Caffeine reduces cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis

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dc.contributor.authorLacorte, Livia M. [UNESP]
dc.contributor.authorSeiva, Fabio R.F. [UNESP]
dc.contributor.authorRinaldi, Jaqueline C. [UNESP]
dc.contributor.authorDelella, Flavia K. [UNESP]
dc.contributor.authorMoroz, Andrei [UNESP]
dc.contributor.authorSarobo, Carolina [UNESP]
dc.contributor.authorGodinho, Antonio F. [UNESP]
dc.contributor.authorFávaro, Wagner J.
dc.contributor.authorFernandes, Ana A.H. [UNESP]
dc.contributor.authorFelisbino, Sérgio L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:27:29Z
dc.date.available2014-05-27T11:27:29Z
dc.date.issued2013-01-01
dc.description.abstractThe aim of this study was to investigate the effects of caffeine (20. mg/L) intake on cadmium (15. mg/L) accumulation in the rat blood, testes, epididymis and prostate as well as cadmium-induced changes to the antioxidant defense system of the epididymis. Caffeine reduced the cadmium concentration in all tissues analyzed. Meanwhile, cadmium reduced catalase activity and increased superoxide dismutase (SOD) activity in the epididymis. Caffeine increased SOD activity, catalase and glutathione tissue expression and sustains the cadmium's effect on catalase and GSP-Px activity. No differences in the expression of metallothionein and lipid peroxidation were observed among the different treatments in the epididymis. In conclusion, low doses of cadmium alter the antioxidant enzymatic profile of the epididymis, but not induced oxidative lipid damage. Caffeine intake reduces overall cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis, thus exerting a protective effect against this metal. © 2012 Elsevier Inc.en
dc.description.affiliationDepartment of Morphology Institute of Biosciences Univ Estadual Paulista, Botucatu, Sao Paulo
dc.description.affiliationCEATOX Institute of Biosciences Univ Estadual Paulista (UNESP), Botucatu, Sao Paulo
dc.description.affiliationDepartment of Chemistry and Biochemistry Institute of Biosciences Univ Estadual Paulista (UNESP), Botucatu, Sao Paulo
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP), Campinas, Sao Paulo
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences Univ Estadual Paulista, Botucatu, Sao Paulo
dc.description.affiliationUnespCEATOX Institute of Biosciences Univ Estadual Paulista (UNESP), Botucatu, Sao Paulo
dc.description.affiliationUnespDepartment of Chemistry and Biochemistry Institute of Biosciences Univ Estadual Paulista (UNESP), Botucatu, Sao Paulo
dc.format.extent137-143
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2012.10.009
dc.identifier.citationReproductive Toxicology, v. 35, n. 1, p. 137-143, 2013.
dc.identifier.doi10.1016/j.reprotox.2012.10.009
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.scopus2-s2.0-84871919665
dc.identifier.urihttp://hdl.handle.net/11449/74194
dc.identifier.wosWOS:000314003900017
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAccumulationen
dc.subjectCadmiumen
dc.subjectCaffeineen
dc.subjectMale reproductive tracten
dc.subjectOxidative stressen
dc.subjectcadmiumen
dc.subjectcaffeineen
dc.subjectcatalaseen
dc.subjectglutathioneen
dc.subjectglutathione peroxidaseen
dc.subjectmetallothioneinen
dc.subjectsuperoxide dismutaseen
dc.subjectanimal cellen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectanimal tissueen
dc.subjectantioxidant activityen
dc.subjectbioaccumulationen
dc.subjectconcentration responseen
dc.subjectcontrolled studyen
dc.subjectdiet supplementationen
dc.subjectenzyme activityen
dc.subjectepididymisen
dc.subjectfluid intakeen
dc.subjectfood intakeen
dc.subjectlipid peroxidationen
dc.subjectmaleen
dc.subjectnonhumanen
dc.subjectoxidative stressen
dc.subjectprotein expressionen
dc.subjectraten
dc.subjectreproductive toxicityen
dc.subjectspermatozoon maturationen
dc.subjecttissue distributionen
dc.subjectupregulationen
dc.subjectWestern blottingen
dc.subjectAnimalsen
dc.subjectCatalaseen
dc.subjectEnvironmental Pollutantsen
dc.subjectEpididymisen
dc.subjectGlutathioneen
dc.subjectGlutathione Peroxidaseen
dc.subjectLipid Peroxidesen
dc.subjectMaleen
dc.subjectOxidative Stressen
dc.subjectProtective Agentsen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectSuperoxide Dismutaseen
dc.subjectTissue Distributionen
dc.subjectRattusen
dc.titleCaffeine reduces cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication
unesp.author.lattes6926124203948011[5]
unesp.author.lattes9719891659222257[7]
unesp.author.orcid0000-0001-6362-5882[4]
unesp.author.orcid0000-0001-5830-8938[8]
unesp.author.orcid0000-0002-7461-8773[2]
unesp.author.orcid0000-0002-4498-9784[5]
unesp.author.orcid0000-0002-2832-8919[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentMorfologia - IBBpt
unesp.departmentBioquímica e Tecnologia - IQpt

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Coleções

Botucatu - IBB - Instituto de Biociências
Araraquara - IQAR - Instituto de Química
Botucatu - CEATOX - Centro de Assistência Toxicológica