Publicação: Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode
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Data
2005-08-01
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Coorientador
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In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E 1/2 = 0.99:V vs. Ag/AgCl sat, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51 ± 0.07) ± 10 -5:cm:s -1, with a αn a value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 ± 10 -5 to 1.0 ± 10 -2:mol:l -1 range, being obtained a detection limit of 2.4 ± 10 -5:mol:l -1. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations. © 2005 Elsevier SAS. All rights reserved.
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Albendazole, Glassy carbon, Rotating disk electrode, Voltammetric determination, albendazole, carbon, silver chloride, drug formulation, electrochemical analysis, electrode, kinetics, methodology, oxidation, potentiometry, Carbon, Electrochemistry, Electrodes, Glass, Oxidation-Reduction, Pharmaceutical Preparations, Rotation
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Inglês
Como citar
Farmaco, v. 60, n. 8, p. 671-674, 2005.
