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Micro-arc oxidation as a tool to develop multifunctional calcium-rich surfaces for dental implant applications

dc.contributor.authorRibeiro, A. R. [UNESP]
dc.contributor.authorOliveira, F.
dc.contributor.authorBoldrini, L. C.
dc.contributor.authorLeite, P. E.
dc.contributor.authorFalagan-lotsch, P.
dc.contributor.authorLinhares, A. B. R.
dc.contributor.authorZambuzzi, W. F. [UNESP]
dc.contributor.authorFragneaud, B.
dc.contributor.authorCampos, A. P. C.
dc.contributor.authorGouvêa, C. P.
dc.contributor.authorArchanjo, B. S.
dc.contributor.authorAchete, C. A.
dc.contributor.authorMarcantonio Júnior, Elcio [UNESP]
dc.contributor.authorRocha, L. A. [UNESP]
dc.contributor.authorGranjeiro, J. M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Minho
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.date.accessioned2015-08-06T16:12:52Z
dc.date.available2015-08-06T16:12:52Z
dc.date.issued2015
dc.description.abstractTitanium (Ti) is commonly used in dental implant applications. Surface modification strategies are being followed in last years in order to build Ti oxide-based surfaces that can fulfill, simultaneously, the following requirements: induced cell attachment and adhesion, while providing a superior corrosion and tribocorrosion performance. In this work micro-arc oxidation (MAO) was used as a tool for the growth of a nanostructured bioactive titanium oxide layer aimed to enhance cell attachment and adhesion for dental implant applications. Characterization of the surfaces was performed, in terms of morphology, topography, chemical composition and crystalline structure. Primary human osteoblast adhesion on the developed surfaces was investigated in detail by electronic and atomic force microscopy as well as immunocytochemistry. Also an investigation on the early cytokine production was performed. Results show that a relatively thick hybrid and graded oxide layer was produced on the Ti surface, being constituted by a mixture of anatase, rutile and amorphous phases where calcium (Ca) and phosphorous (P) were incorporated. An outermost nanometric-thick amorphous oxide layer rich in Ca was present in the film. This amorphous layer, rich in Ca, improved fibroblast viability and metabolic activity as well as osteoblast adhesion. High-resolution techniques allowed to understand that osteoblasts adhered less in the crystalline-rich regions while they preferentially adhere and spread over in the Ca-rich amorphous oxide layer. Also, these surfaces induce higher amounts of IFN-γ cytokine secretion, which is known to regulate inflammatory responses, bone microarchitecture as well as cytoskeleton reorganization and cellular spreading. These surfaces are promising in the context of dental implants, since they might lead to faster osseointegration.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, RUA HUMAITÁ Nº 1680, CENTRO, CEP 14801903, SP, Brasil
dc.description.affiliationDepartment of Periodontology, Araraquara Dental School, University Estadual Paulista, Rua Humaitá 1680, 14801-903 Araraquara, São Paulo, Brazil
dc.description.affiliationDirectory of Metrology Applied to Life Science, National Institute of Metrology Quality and Technology, Av. N. S. das Graças 50, Xerém, Duque de Caxias, Rio de Janeiro, Brazil
dc.description.affiliationBrazilian Branch of Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN/Br), Brazil
dc.description.affiliationCentre for Mechanical and Materials Technologies, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
dc.description.affiliationClinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niterói, Brazil
dc.description.affiliationPhysics Department, Federal University of Juiz de Fora (UFJF), Rua José Lourenço Kelmer, 36036-900 Minas Gerais, Brazil
dc.description.affiliationMetrology Materials Division, National Institute of Metrology Quality and Technology, Av. N. S. das Graças 50, Xerém, Duque de Caxias, Rio de Janeiro, Brazil
dc.description.affiliationDental School, Fluminense Federal University, Niterói, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, RUA HUMAITÁ Nº 1680, CENTRO, CEP 14801903, SP, Brasil
dc.description.affiliationUnespDepartment of Periodontology, Araraquara Dental School, University Estadual Paulista, Rua Humaitá 1680, 14801-903 Araraquara, São Paulo, Brazil
dc.description.affiliationUnespDepartamento de Química e Bioquímica, Universidade Estadual Paulista — UNESP, Distrito de Rubião Junior S/N, 18618-970 Botucatu, São Paulo, Brazil
dc.description.affiliationUnespDepartamento de Física, Universidade Estadual Paulista — UNESP, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01 Bauru, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)
dc.description.sponsorshipIdFAPESP: 2012/03633-1
dc.description.sponsorshipIdCNPq: 490761/2013-5
dc.description.sponsorshipIdCNPq/PROMETRO: 563165/2010-3F
dc.description.sponsorshipIdSFRH/BD: 70857/2010
dc.description.sponsorshipIdPTDC/CTM: 68160/2006
dc.description.sponsorshipIdPTDC/CTM: 67500/2006
dc.description.sponsorshipIdCAPES/PVE: 1317/11-3
dc.format.extent196-206
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0928493115300618
dc.identifier.citationMaterials Science & Engineering. C, Biomimetic Materials, Sensors and Systems, v. 54, p. 196-206, 2015.
dc.identifier.doi10.1016/j.msec.2015.05.012
dc.identifier.issn0928-4931
dc.identifier.lattes6100859465871929
dc.identifier.urihttp://hdl.handle.net/11449/125702
dc.language.isoeng
dc.relation.ispartofMaterials Science & Engineering. C, Biomimetic Materials, Sensors and Systems
dc.relation.ispartofjcr5.080
dc.relation.ispartofsjr1,110
dc.rights.accessRightsAcesso restritopt
dc.sourceCurrículo Lattes
dc.subjectMicro-arc-oxidationen
dc.subjectCalciumen
dc.subjectPhosphorusen
dc.subjectTitaniumen
dc.subjectHuman bone-derived cellsen
dc.subjectAdhesionen
dc.subjectBiointerphaseen
dc.titleMicro-arc oxidation as a tool to develop multifunctional calcium-rich surfaces for dental implant applicationsen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.author.lattes6100859465871929
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentDiagnóstico e Cirurgia - FOARpt
unesp.departmentFísica - FCpt
unesp.departmentQuímica e Bioquímica - IBBpt

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