Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
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Data
Autores
Orientador
Silva, Cristina Antoniali 
Coorientador
Chaves Neto, Antonio Hernandes
Pós-graduação
Ciências - FOA
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Tipo
Dissertação de mestrado
Direito de acesso
Acesso aberto
Resumo
Resumo (inglês)
Saliva contains oxidative stress biomarkers, whose expression may be altered by the presence of caries. This study evaluated whether atraumatic restorative treatment (art) alters the concentration of total proteins and nitric oxide in the saliva of children with caries at different stages. A total of 45 children, aged 4 to 6 years, attending EMEB schools in Araçatuba, SP, were selected and divided into three groups: caries-free, enamel caries, and dentin caries. Unstimulated saliva samples were collected before, immediately after, and 21 days after clinical treatment, in which carious lesions were restored with glass ionomer cement. The collection protocol restricted the use of fluoridated products. Pre-standardized biochemical experiments were conducted to assess the concentration of total proteins and salivary nitrite (no₂⁻).. Art did not alter salivary nitrite (no₂⁻) concentration in children with caries, but increased total protein concentration, with noticeable effects 21 days after the intervention, particularly in children with dentin caries. These findings indicate that art modifies the oral environment, emphasizing the importance of integrating research, education, and clinical strategies to optimize caries prevention and control.
Resumo (inglês)
Saliva contains oxidative stress biomarkers, whose expression may be altered by the presence of caries. This study evaluated whether atraumatic restorative treatment (art) alters the concentration of total proteins and nitric oxide in the saliva of children with caries at different stages. A total of 45 children, aged 4 to 6 years, attending EMEB schools in Araçatuba, SP, were selected and divided into three groups: caries-free,
enamel caries, and dentin caries. Unstimulated saliva samples were collected before, immediately after, and 21 days after clinical treatment, in which carious lesions were restored with glass ionomer cement. The collection protocol restricted the use of fluoridated products. Pre-standardized biochemical experiments were conducted to assess the concentration of total proteins and salivary nitrite (no₂⁻).. Art did not alter
salivary nitrite (no₂⁻) concentration in children with caries, but increased total protein concentration, with noticeable effects 21 days after the intervention, particularly in children with dentin caries. These findings indicate that art modifies the oral environment, emphasizing the importance of integrating research, education, and clinical strategies to optimize caries prevention and control.
Descrição
Palavras-chave
Saliva, Cáries dentárias, Marcadores bioquímicos, Proteínas salivares, Oxido nitrico, Tratamento odontológico restaurador sem trauma, Dental caries
Idioma
Português
Citação
MATEUS, A. R. Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar. 2025. Dissertação Mestrado – Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Araçatuba, 2025.
