Publicação:
Hepatocyte lesions and cellular immune response in yellow fever infection

dc.contributor.authorQuaresma, Juarez A. S.
dc.contributor.authorBarros, Vera L. R. S.
dc.contributor.authorPagliari, Carla
dc.contributor.authorFernandes, Elaine R.
dc.contributor.authorAndrade, Heitor F.
dc.contributor.authorVasconcelos, Pedro F. C.
dc.contributor.authorDuarte, Maria I. S.
dc.contributor.institutionFed Univ Para
dc.contributor.institutionState Univ Para
dc.contributor.institutionMinist Hlth
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:50Z
dc.date.available2014-05-20T15:21:50Z
dc.date.issued2007-02-01
dc.description.abstractThe study of the in-situ cellular immune response is very important for the understanding of different liver infections. In the present study, 53 liver samples obtained by viscerotomy from patients who died during the course of jungle yellow fever were analyzed. The diagnosis was confirmed by serology, viral isolation and virus-specific immunohistochemistry. The specimens were analyzed by immunohistochemistry using specific antibodies for apoptosis, CD45RO, CD4, CD8, CD20, S100, CD57 and CD68. Quantitative analysis of the labeling pattern showed a clear predominance of the different phenotypes in the portal tract and midzone region of the acini. There was a predominance of T CD4+ lymphocytes, accompanied by the presence of T CD8+ lymphocytes, natural killer cells (CD57), macrophages and antigen-presenting cells (S100). The disproportion between the intensity of inflammation and the degree of hepatic injury was probably due to the intense apoptotic component, which classically does not induce an inflammatory response. The present study demonstrates that, despite the disproportion between injury and inflammation, the cellular immune response plays an important role in the pathogenesis of the hepatocytic injury observed in yellow fever, probably as a result of cytolytic actions through mechanisms involving MHC II and the activation of Fas receptors and granzymes/perforins. (C) 2006 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationFed Univ Para, Trop Med Ctr, BR-66055240 Belem, Para, Brazil
dc.description.affiliationState Univ Para, Dept Pathol, BR-66087070 Belem, Para, Brazil
dc.description.affiliationMinist Hlth, Evandro Chagas Inst, BR-66090000 Belem, Para, Brazil
dc.description.affiliationState Univ São Paulo, Fac Med, BR-01246903 São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Fac Med, BR-01246903 São Paulo, Brazil
dc.format.extent161-168
dc.identifierhttp://dx.doi.org/10.1016/j.trstmh.2006.02.019
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. New York: Elsevier B.V., v. 101, n. 2, p. 161-168, 2007.
dc.identifier.doi10.1016/j.trstmh.2006.02.019
dc.identifier.issn0035-9203
dc.identifier.urihttp://hdl.handle.net/11449/32933
dc.identifier.wosWOS:000243708200010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.relation.ispartofjcr2.820
dc.relation.ispartofsjr1,174
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectyellow feverpt
dc.subjectarboviruspt
dc.subjectFlaviviruspt
dc.subjectimmunologicpt
dc.subjectmarkerspt
dc.subjectapoptosispt
dc.subjectBrazilpt
dc.titleHepatocyte lesions and cellular immune response in yellow fever infectionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication

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